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dc.contributor.authorValerio, Fernanda
dc.contributor.authorWhitehouse, Daniel P.
dc.contributor.authorMenon, David K.
dc.contributor.authorNewcombe, Virginia F. J.
dc.date.accessioned2021-10-28T08:07:58Z
dc.date.available2021-10-28T08:07:58Z
dc.date.issued2020-10-26
dc.date.submitted2020-06-30
dc.identifier.issn0340-5354
dc.identifier.others00415-020-10261-3
dc.identifier.other10261
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329978
dc.descriptionFunder: NIHR Cambridge Biomedical Research Centre (GB)
dc.descriptionFunder: University of Cambridge
dc.description.abstractAbstract: Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limited treatments often available. The under-recognition of neurological manifestations may lead to an increase in the burden of acute disease as well as secondary complications with long-term consequences. Nervous system infection or dysfunction during pandemics is common and its enduring consequences, especially among vulnerable populations, are frequently forgotten. An improved understanding the possible mechanisms of neurological damage during epidemics, and increased recognition of the possible manifestations is fundamental to bring insights when dealing with future outbreaks. To reverse this gap in knowledge, we reviewed all the pandemics, large and important epidemics of human history in which neurological manifestations are evident, and described the possible physiological processes that leads to the adverse sequelae caused or triggered by those pathogens.
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.subjectReview
dc.subjectCOVID-19
dc.subjectCNS infections
dc.subjectPeripheral neuropathies
dc.subjectPandemics/history
dc.subjectMeningitis
dc.subjectEncephalitis
dc.titleThe neurological sequelae of pandemics and epidemics
dc.typeArticle
dc.date.updated2021-10-28T08:07:57Z
prism.endingPage2655
prism.issueIdentifier8
prism.publicationNameJournal of Neurology
prism.startingPage2629
prism.volume268
dc.identifier.doi10.17863/CAM.77422
dcterms.dateAccepted2020-10-07
rioxxterms.versionofrecord10.1007/s00415-020-10261-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidValerio, Fernanda [0000-0001-5248-7314]
dc.identifier.eissn1432-1459


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