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dc.contributor.authorHanashima, Shinya
dc.contributor.authorNakane, Takanori
dc.contributor.authorMizohata, Eiichi
dc.date.accessioned2021-10-29T06:14:30Z
dc.date.available2021-10-29T06:14:30Z
dc.date.issued2021-10-27
dc.identifier.issn2077-0375
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330032
dc.description.abstractMembrane proteins reside in the lipid bilayer of biomembranes and the structure and function of these proteins are closely related to their interactions with lipid molecules. Structural analyses of interactions between membrane proteins and lipids or detergents that constitute biological or artificial model membranes are important for understanding the functions and physicochemical properties of membrane proteins and biomembranes. Determination of membrane protein structures is much more difficult when compared with that of soluble proteins, but the development of various new technologies has accelerated the elucidation of the structure-function relationship of membrane proteins. This review summarizes the development of heavy atom derivative detergents and lipids that can be used for structural analysis of membrane proteins and their interactions with detergents/lipids, including their application with X-ray free-electron laser crystallography.
dc.languageen
dc.publisherMDPI AG
dc.subjectmembrane protein
dc.subjectlipid
dc.subjectdetergent
dc.subjectchemical synthesis
dc.subjectX-ray free-electron laser (XFEL)
dc.subjectserial femtosecond crystallography (SFX)
dc.subjectstructure-function relationship
dc.titleHeavy Atom Detergent/Lipid Combined X-ray Crystallography for Elucidating the Structure-Function Relationships of Membrane Proteins.
dc.typeArticle
dc.date.updated2021-10-29T06:14:29Z
prism.issueIdentifier11
prism.publicationNameMembranes (Basel)
prism.volume11
dc.identifier.doi10.17863/CAM.77476
dcterms.dateAccepted2021-10-23
rioxxterms.versionofrecord10.3390/membranes11110823
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidHanashima, Shinya [0000-0003-3102-7890]
dc.contributor.orcidNakane, Takanori [0000-0003-2697-2767]
dc.contributor.orcidMizohata, Eiichi [0000-0002-5526-5343]
dc.identifier.eissn2077-0375
pubs.funder-project-idJapan Science and Technology Agency (JPMJPR17GB, The ERATO active lipid structure project)
pubs.funder-project-idMinistry of Education, Culture, Sports, Science and Technology (19H05780, The X-ray Free Electron Laser Priority Strategy Program)
pubs.funder-project-idJapan Society for the Promotion of Science (16H06315)
cam.issuedOnline2021-10-27


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