Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies.
Staab, Jeffrey P
J Clin Med
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Indovina, I., Passamonti, L., Mucci, V., Chiarella, G., Lacquaniti, F., & Staab, J. P. (2021). Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies.. J Clin Med, 10 (18) https://doi.org/10.3390/jcm10184274
Persistent postural-perceptual dizziness (PPPD), defined in 2017, is a vestibular disorder characterized by chronic dizziness that is exacerbated by upright posture and exposure to complex visual stimuli. This review focused on recent neuroimaging studies that explored the pathophysiological mechanisms underlying PPPD and three conditions that predated it. The emerging picture is that local activity and functional connectivity in multimodal vestibular cortical areas are decreased in PPPD, which is potentially related to structural abnormalities (e.g., reductions in cortical folding and grey-matter volume). Additionally, connectivity between the prefrontal cortex, which regulates attentional and emotional responses, and primary visual and motor regions appears to be increased in PPPD. These results complement physiological and psychological data identifying hypervigilant postural control and visual dependence in patients with PPPD, supporting the hypothesis that PPPD arises from shifts in interactions among visuo-vestibular, sensorimotor, and emotional networks that overweigh visual over vestibular inputs and increase the effects of anxiety-related mechanisms on locomotor control and spatial orientation.
Neuroimaging, Chronic Subjective Dizziness, Phobic Postural Vertigo, Visual Dependency, Persistent Postural-perceptual Dizziness, Visually Induced Dizziness
Italian Ministry of Health (IRCCS Fondazione Santa Lucia Ricerca Corrente)
U.S. Department of Defense (W81XWH1810760 PT170028)
External DOI: https://doi.org/10.3390/jcm10184274
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330079
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/