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dc.contributor.authorIndovina, Iole
dc.contributor.authorPassamonti, Luca
dc.contributor.authorMucci, Viviana
dc.contributor.authorChiarella, Giuseppe
dc.contributor.authorLacquaniti, Francesco
dc.contributor.authorStaab, Jeffrey P
dc.date.accessioned2021-10-30T01:12:03Z
dc.date.available2021-10-30T01:12:03Z
dc.date.issued2021-09-21
dc.identifier.issn2077-0383
dc.identifier.otherPMC8468644
dc.identifier.other34575385
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330079
dc.description.abstractPersistent postural-perceptual dizziness (PPPD), defined in 2017, is a vestibular disorder characterized by chronic dizziness that is exacerbated by upright posture and exposure to complex visual stimuli. This review focused on recent neuroimaging studies that explored the pathophysiological mechanisms underlying PPPD and three conditions that predated it. The emerging picture is that local activity and functional connectivity in multimodal vestibular cortical areas are decreased in PPPD, which is potentially related to structural abnormalities (e.g., reductions in cortical folding and grey-matter volume). Additionally, connectivity between the prefrontal cortex, which regulates attentional and emotional responses, and primary visual and motor regions appears to be increased in PPPD. These results complement physiological and psychological data identifying hypervigilant postural control and visual dependence in patients with PPPD, supporting the hypothesis that PPPD arises from shifts in interactions among visuo-vestibular, sensorimotor, and emotional networks that overweigh visual over vestibular inputs and increase the effects of anxiety-related mechanisms on locomotor control and spatial orientation.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2077-0383
dc.sourcenlmid: 101606588
dc.subjectNeuroimaging
dc.subjectChronic Subjective Dizziness
dc.subjectPhobic Postural Vertigo
dc.subjectVisual Dependency
dc.subjectPersistent Postural-perceptual Dizziness
dc.subjectVisually Induced Dizziness
dc.titleBrain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies.
dc.typeArticle
dc.date.updated2021-10-30T01:12:02Z
prism.issueIdentifier18
prism.publicationNameJ Clin Med
prism.volume10
dc.identifier.doi10.17863/CAM.77523
dcterms.dateAccepted2021-09-15
rioxxterms.versionofrecord10.3390/jcm10184274
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidIndovina, Iole [0000-0002-1183-0013]
dc.contributor.orcidPassamonti, Luca [0000-0002-7937-0615]
dc.contributor.orcidChiarella, Giuseppe [0000-0002-9829-2229]
dc.contributor.orcidLacquaniti, Francesco [0000-0003-0896-7315]
dc.identifier.eissn2077-0383
pubs.funder-project-idItalian Ministry of Health (IRCCS Fondazione Santa Lucia Ricerca Corrente)
pubs.funder-project-idU.S. Department of Defense (W81XWH1810760 PT170028)
cam.issuedOnline2021-09-21


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International