Show simple item record

dc.contributor.authorWallace, Chris
dc.date.accessioned2021-10-31T00:50:10Z
dc.date.available2021-10-31T00:50:10Z
dc.date.issued2021-09-29
dc.identifier.issn1553-7390
dc.identifier.otherPMC8504726
dc.identifier.other34587156
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330116
dc.description.abstractIn genome-wide association studies (GWAS) it is now common to search for, and find, multiple causal variants located in close proximity. It has also become standard to ask whether different traits share the same causal variants, but one of the popular methods to answer this question, coloc, makes the simplifying assumption that only a single causal variant exists for any given trait in any genomic region. Here, we examine the potential of the recently proposed Sum of Single Effects (SuSiE) regression framework, which can be used for fine-mapping genetic signals, for use with coloc. SuSiE is a novel approach that allows evidence for association at multiple causal variants to be evaluated simultaneously, whilst separating the statistical support for each variant conditional on the causal signal being considered. We show this results in more accurate coloc inference than other proposals to adapt coloc for multiple causal variants based on conditioning. We therefore recommend that coloc be used in combination with SuSiE to optimise accuracy of colocalisation analyses when multiple causal variants exist.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1553-7404
dc.sourcenlmid: 101239074
dc.titleA more accurate method for colocalisation analysis allowing for multiple causal variants.
dc.typeArticle
dc.date.updated2021-10-31T00:50:09Z
prism.issueIdentifier9
prism.publicationNamePLoS genetics
prism.volume17
dc.identifier.doi10.17863/CAM.77560
rioxxterms.versionofrecord10.1371/journal.pgen.1009440
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWallace, Chris [0000-0001-9755-1703]
pubs.funder-project-idNIHR Cambridge BRC (BRC-1215-20014)
pubs.funder-project-idMedical Research Council (MC UU 00002/4)
pubs.funder-project-idWellcome Trust (WT107881, WT220788)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International