Organoid systems to study the human female reproductive tract and pregnancy
Publication Date
2020-06-03Journal Title
Cell Death & Differentiation
ISSN
1350-9047
Publisher
Nature Publishing Group UK
Volume
28
Issue
1
Pages
35-51
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Alzamil, L., Nikolakopoulou, K., & Turco, M. Y. (2020). Organoid systems to study the human female reproductive tract and pregnancy. Cell Death & Differentiation, 28 (1), 35-51. https://doi.org/10.1038/s41418-020-0565-5
Description
Funder: Centre for Trophoblast Research L'Oreal Women in Science Fellowship
Abstract
Abstract: Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women’s health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developments in 3D organoid technology that model the different regions of the FRT include organoids of the ovaries, fallopian tubes, endometrium and cervix, as well as placental trophoblast. These models are opening up new avenues to investigate the normal biology and pathology of the FRT. In this review, we discuss the advances, potential, and limitations of organoid cultures of the human FRT.
Keywords
Review Article, /631/80, /631/443, /692/699, /13, /13/107, /38, /13/100, /13/106, review-article
Sponsorship
Royal Society (DH160216)
Isaac Newton Trust (G100391)
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) (853546)
King Saud University (KSU) (KSU1520)
Wellcome Trust (Wellcome) (UNS13724)
Identifiers
s41418-020-0565-5, 565
External DOI: https://doi.org/10.1038/s41418-020-0565-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330141
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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