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dc.contributor.authorBoshier, Florencia AT
dc.contributor.authorVenturini, Cristina
dc.contributor.authorStirrup, Oliver
dc.contributor.authorGuerra-Assunção, José Afonso
dc.contributor.authorAlcolea-Medina, Adela
dc.contributor.authorBecket, Angela H
dc.contributor.authorByott, Matthew
dc.contributor.authorCharalampous, Themoula
dc.contributor.authorFilipe, Ana da Silva
dc.contributor.authorFrampton, Dan
dc.contributor.authorGlaysher, Sharon
dc.contributor.authorKhan, Tabassum
dc.contributor.authorKulasegara-Shylini, Raghavendran
dc.contributor.authorKele, Beatrix
dc.contributor.authorMonahan, Irene M
dc.contributor.authorMollett, Guy
dc.contributor.authorParker, Matthew
dc.contributor.authorPelosi, Emanuela
dc.contributor.authorRandell, Paul
dc.contributor.authorRoy, Sunando
dc.contributor.authorTaylor, Joshua F
dc.contributor.authorWeller, Sophie J
dc.contributor.authorWilson-Davies, Eleri
dc.contributor.authorWade, Phillip
dc.contributor.authorWilliams, Rachel
dc.contributor.authorCopas, Andrew J
dc.contributor.authorCutino-Moguel, Teresa
dc.contributor.authorFreemantle, Nick
dc.contributor.authorHayward, Andrew C
dc.contributor.authorHolmes, Alison
dc.contributor.authorHughes, Joseph
dc.contributor.authorMahungu, Tabitha W
dc.contributor.authorNebbia, Gaia
dc.contributor.authorNastouli, Eleni
dc.contributor.authorPartridge, David G
dc.contributor.authorPope, Cassie F
dc.contributor.authorPrice, James R
dc.contributor.authorRobson, Samuel C
dc.contributor.authorSaeed, Kordo
dc.contributor.authorShin, Gee Yen
dc.contributor.authorde Silva, Thushan I
dc.contributor.authorSnell, Luke B
dc.contributor.authorThomson, Emma C
dc.contributor.authorWitney, Adam A
dc.contributor.authorBreuer, Judith
dc.contributor.authorCOG-UK HOCI Variant Substudy consortium*, The COVID-19 Genomics UK (COG-UK) consortium
dc.date.accessioned2021-11-02T00:30:07Z
dc.date.available2021-11-02T00:30:07Z
dc.date.issued2021-12
dc.identifier.issn0163-4453
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330149
dc.description.abstractOBJECTIVES: Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals. METHODS: We collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences. RESULTS: Mixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages. CONCLUSIONS: We find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern.
dc.description.sponsorshipCOG-UK HOCI funded by COG-UK consortium. The COG-UK consortium is supported by funding from the Medical Research Council (MRC) part of UK Research & Innovation (UKRI), the National Institute of Health Research (NIHR) and Genome Research Limited, operating as the Wellcome Sanger Institute.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOG-UK HOCI Variant Substudy consortium*, The COVID-19 Genomics UK (COG-UK) consortium
dc.titleThe Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameJ Infect
dc.identifier.doi10.17863/CAM.77592
dcterms.dateAccepted2021-09-12
rioxxterms.versionofrecord10.1016/j.jinf.2021.09.022
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-10-02
dc.contributor.orcidVenturini, Cristina [0000-0002-4769-7912]
dc.contributor.orcidCopas, Andrew J [0000-0001-8968-5963]
dc.contributor.orcidRobson, Samuel C [0000-0001-5702-9160]
dc.contributor.orcidBreuer, Judith [0000-0001-8246-0534]
dc.identifier.eissn1532-2742
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (MC_PC_19027)
pubs.funder-project-idMedical Research Council (MC_PC_19027)
cam.issuedOnline2021-10-02


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International