Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
View / Open Files
Authors
Jonkman, Sietse
O'Connor, Richard M
Romano, Michael F
Publication Date
2021-08-25Journal Title
Nat Commun
ISSN
2041-1723
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Pages
5121
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Smith, A. C., Jonkman, S., Difeliceantonio, A. G., O'Connor, R. M., Ghoshal, S., Romano, M. F., Everitt, B. J., & et al. (2021). Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.. Nat Commun, 12 (1), 5121. https://doi.org/10.1038/s41467-021-25460-3
Abstract
Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions.
Keywords
Corpus Striatum, Neurons, Animals, Mice, Inbred C57BL, Mice, Rats, Rats, Long-Evans, Receptors, Dopamine D1, Receptors, Dopamine D2, Behavior, Animal, Conditioning, Operant, Male
Sponsorship
Medical Research Council (MR/N02530X/1)
Identifiers
External DOI: https://doi.org/10.1038/s41467-021-25460-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330153
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.