Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
O'Connor, Richard M
Romano, Michael F
Springer Science and Business Media LLC
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Smith, A. C., Jonkman, S., Difeliceantonio, A. G., O'Connor, R. M., Ghoshal, S., Romano, M. F., Everitt, B. J., & et al. (2021). Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.. Nat Commun, 12 (1), 5121. https://doi.org/10.1038/s41467-021-25460-3
Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions.
Corpus Striatum, Neurons, Animals, Mice, Inbred C57BL, Mice, Rats, Rats, Long-Evans, Receptors, Dopamine D1, Receptors, Dopamine D2, Behavior, Animal, Conditioning, Operant, Male
Medical Research Council (MR/N02530X/1)
External DOI: https://doi.org/10.1038/s41467-021-25460-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330153
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/