Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
dc.contributor.author | Smith, Alexander CW | |
dc.contributor.author | Jonkman, Sietse | |
dc.contributor.author | Difeliceantonio, Alexandra G | |
dc.contributor.author | O'Connor, Richard M | |
dc.contributor.author | Ghoshal, Soham | |
dc.contributor.author | Romano, Michael F | |
dc.contributor.author | Everitt, Barry | |
dc.contributor.author | Kenny, Paul J | |
dc.date.accessioned | 2021-11-02T00:30:17Z | |
dc.date.available | 2021-11-02T00:30:17Z | |
dc.date.issued | 2021-08-25 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/330153 | |
dc.description.abstract | Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions. | |
dc.format.medium | Electronic | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Corpus Striatum | |
dc.subject | Neurons | |
dc.subject | Animals | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice | |
dc.subject | Rats | |
dc.subject | Rats, Long-Evans | |
dc.subject | Receptors, Dopamine D1 | |
dc.subject | Receptors, Dopamine D2 | |
dc.subject | Behavior, Animal | |
dc.subject | Conditioning, Operant | |
dc.subject | Male | |
dc.title | Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions. | |
dc.type | Article | |
prism.issueIdentifier | 1 | |
prism.publicationDate | 2021 | |
prism.publicationName | Nat Commun | |
prism.startingPage | 5121 | |
prism.volume | 12 | |
dc.identifier.doi | 10.17863/CAM.77596 | |
dcterms.dateAccepted | 2021-08-11 | |
rioxxterms.versionofrecord | 10.1038/s41467-021-25460-3 | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2021-08-25 | |
dc.contributor.orcid | Smith, Alexander CW [0000-0001-7724-6234] | |
dc.contributor.orcid | Difeliceantonio, Alexandra G [0000-0002-7155-6060] | |
dc.contributor.orcid | Ghoshal, Soham [0000-0001-9078-8978] | |
dc.contributor.orcid | Everitt, Barry [0000-0003-4431-6536] | |
dc.contributor.orcid | Kenny, Paul J [0000-0003-2426-3641] | |
dc.identifier.eissn | 2041-1723 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | Medical Research Council (MR/N02530X/1) | |
cam.issuedOnline | 2021-08-25 |
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