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dc.contributor.authorSmith, Alexander CW
dc.contributor.authorJonkman, Sietse
dc.contributor.authorDifeliceantonio, Alexandra G
dc.contributor.authorO'Connor, Richard M
dc.contributor.authorGhoshal, Soham
dc.contributor.authorRomano, Michael F
dc.contributor.authorEveritt, Barry
dc.contributor.authorKenny, Paul J
dc.date.accessioned2021-11-02T00:30:17Z
dc.date.available2021-11-02T00:30:17Z
dc.date.issued2021-08-25
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330153
dc.description.abstractComparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCorpus Striatum
dc.subjectNeurons
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectMice
dc.subjectRats
dc.subjectRats, Long-Evans
dc.subjectReceptors, Dopamine D1
dc.subjectReceptors, Dopamine D2
dc.subjectBehavior, Animal
dc.subjectConditioning, Operant
dc.subjectMale
dc.titleOpposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2021
prism.publicationNameNat Commun
prism.startingPage5121
prism.volume12
dc.identifier.doi10.17863/CAM.77596
dcterms.dateAccepted2021-08-11
rioxxterms.versionofrecord10.1038/s41467-021-25460-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-08-25
dc.contributor.orcidSmith, Alexander CW [0000-0001-7724-6234]
dc.contributor.orcidDifeliceantonio, Alexandra G [0000-0002-7155-6060]
dc.contributor.orcidGhoshal, Soham [0000-0001-9078-8978]
dc.contributor.orcidEveritt, Barry [0000-0003-4431-6536]
dc.contributor.orcidKenny, Paul J [0000-0003-2426-3641]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-08-25


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International