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dc.contributor.authorTodd, Kendra R
dc.contributor.authorvan der Scheer, Jan
dc.contributor.authorWalsh, Jeremy J
dc.contributor.authorJackson, Garett S
dc.contributor.authorDix, Gabriel U
dc.contributor.authorLittle, Jonathan Peter
dc.contributor.authorKramer, John LK
dc.contributor.authorMartin Ginis, Kathleen A
dc.date.accessioned2021-11-02T00:30:30Z
dc.date.available2021-11-02T00:30:30Z
dc.date.issued2021-10-26
dc.identifier.issn2673-6861
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330159
dc.description.abstract<jats:p><jats:bold>Introduction:</jats:bold> Persons with spinal cord injury (SCI) often report high levels of neuropathic pain (NP) and poor well-being, which may result from increased inflammation. This study examined the impact of sub-maximal aerobic exercise on NP, inflammation and psychological affect among adults with SCI.</jats:p><jats:p><jats:bold>Methods:</jats:bold> Eight active adults with tetraplegia (<jats:italic>n</jats:italic>-4, AIS A-C) and paraplegia (<jats:italic>n</jats:italic> = 4, AIS A-C) performed 30-min of arm-crank aerobic exercise and reported their ratings of perceived exertion (RPE) each minute. Measures of NP, affect, and inflammatory cytokines (IL-6, IL-10, IL-1ra, TNF-α) were taken pre-(T<jats:sub>0</jats:sub>), immediately post-(T<jats:sub>1</jats:sub>), and 90-min post-exercise (T<jats:sub>2</jats:sub>).</jats:p><jats:p><jats:bold>Results:</jats:bold> NP decreased between T<jats:sub>0</jats:sub> and T<jats:sub>1</jats:sub> for tetraplegics (−60%, <jats:italic>d</jats:italic> = 0.47; CI = −0.32, 2.02) and paraplegics (−16%, <jats:italic>d</jats:italic> = 0.15; CI = −0.30, 0.90). Correlations between change in cytokines and change in NP were medium-to large for tetraplegics (<jats:italic>rs</jats:italic> ranged from −0.820 to 0.965) and paraplegics (<jats:italic>rs</jats:italic> ranged from −0.598 to 0.833). However, the pattern of correlations between change in cytokines and affect was inconsistent between groups. Lower baseline levels of IL-1ra predicted greater decreases in NP immediately post-exercise (<jats:italic>r</jats:italic> = 0.83, <jats:italic>p</jats:italic> = 0.01).</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> Sub-maximal exercise can positively impact NP for some persons with SCI. Further experimental research should identify the optimal exercise intensity to reduce NP for persons with SCI, in addition to understanding biomarkers which may predict changes in NP.</jats:p><jats:p><jats:bold>Clinical Trial Registration:</jats:bold><jats:ext-link>www.ClinicalTrials.gov</jats:ext-link>, identifier NCT03955523.</jats:p>
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Impact of Sub-maximal Exercise on Neuropathic Pain, Inflammation, and Affect Among Adults With Spinal Cord Injury: A Pilot Study
dc.typeArticle
prism.publicationNameFrontiers in Rehabilitation Sciences
prism.volume2
dc.identifier.doi10.17863/CAM.77602
dcterms.dateAccepted2021-09-29
rioxxterms.versionofrecord10.3389/fresc.2021.700780
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.contributor.orcidvan der Scheer, Jan [0000-0002-4368-0355]
dc.identifier.eissn2673-6861
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-10-26


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International