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dc.contributor.authorFerhati, Xhenti
dc.contributor.authorSalas-Cubero, Marina
dc.contributor.authorGarrido, Pablo
dc.contributor.authorGarcía-Sanmartín, Josune
dc.contributor.authorGuerreiro, Ana
dc.contributor.authorAvenoza, Alberto
dc.contributor.authorBusto, Jesús H
dc.contributor.authorPeregrina, Jesús M
dc.contributor.authorMartínez, Alfredo
dc.contributor.authorJiménez-Moreno, Ester
dc.contributor.authorLopes Bernardes, Goncalo
dc.contributor.authorCorzana, Francisco
dc.date.accessioned2021-11-03T00:30:22Z
dc.date.available2021-11-03T00:30:22Z
dc.date.issued2021-11-05
dc.identifier.issn1523-7060
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330210
dc.description.abstractA self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa promotes fragmentation even at slightly acidic pH, a common feature of several tumor environments. The Grob fragmentation can also occur under physiological conditions in living cells, highlighting the potential bioorthogonal applicability of this reaction.
dc.languageeng
dc.publisherAmerican Chemical Society (ACS)
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleBioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
dc.typeArticle
prism.endingPage8584
prism.issueIdentifier21
prism.publicationDate2021
prism.publicationNameOrg Lett
prism.startingPage8580
prism.volume23
dc.identifier.doi10.17863/CAM.77652
dcterms.dateAccepted2021-10-22
rioxxterms.versionofrecord10.1021/acs.orglett.1c03299
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-05
dc.contributor.orcidGarrido, Pablo [0000-0002-5960-8569]
dc.contributor.orcidGarcía-Sanmartín, Josune [0000-0003-4391-5537]
dc.contributor.orcidBusto, Jesús H [0000-0003-4403-4790]
dc.contributor.orcidPeregrina, Jesús M [0000-0003-3778-7065]
dc.contributor.orcidMartínez, Alfredo [0000-0003-4882-4044]
dc.contributor.orcidJiménez-Moreno, Ester [0000-0002-5045-433X]
dc.contributor.orcidLopes Bernardes, Goncalo [0000-0001-6594-8917]
dc.contributor.orcidCorzana, Francisco [0000-0001-5597-8127]
dc.identifier.eissn1523-7052
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (675007)
cam.issuedOnline2021-10-25
cam.orpheus.success2021-11-02 - Embargo set during processing via Fast-track
rioxxterms.freetoread.startdate2022-10-25


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