Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.
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Authors
Potter, Barney I
Niatou-Singa, Frédéric S
Tombolomako, Thais B
Fuh-Neba, Terence
Vickos, Ulrich
Ulrich, Markus
Khan, Kamran
Watts, Alexander
Olendraitė, Ingrida
Snijder, Joost
Wijnant, Kim N
Martres, Pascale
Behillil, Sylvie
Ayouba, Ahidjo
Djomsi, Dowbiss Meta
Godwe, Celestin
Butel, Christelle
Šimaitis, Aistis
Katėnaitė, Monika
Norvilas, Rimvydas
Raugaitė, Ligita
Koyaweda, Giscard Wilfried
Kandou, Jephté Kaleb
Jonikas, Rimvydas
Nasvytienė, Inga
Žemeckienė, Živilė
Gečys, Dovydas
Žiogienė, Danguolė
Timinskas, Albertas
Šarauskas, Mantas
Alzbutas, Gediminas
Lusamaki, Eddy Kinganda
Mawete, Francisca Muyembe
Lofiko, Emmanuel Lokilo
Kingebeni, Placide Mbala
Tamfum, Jean-Jacques Muyembe
Belizaire, Marie Roseline Darnycka
Essomba, René Ghislain
Assoumou, Marie Claire Okomo
Mboringong, Akenji Blaise
Dieng, Alle Baba
Obama, Justino
Ayekaba, Mitoha Ondo'o
Pautienius, Arnoldas
Rafaï, Clotaire Donatien
Vitkauskienė, Astra
Ugenskienė, Rasa
Čereškevičius, Darius
Lesauskaitė, Vaiva
Žemaitis, Lukas
Griškevičius, Laimonas
Publication Date
2021-10-01Journal Title
Nat Commun
ISSN
2041-1723
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Dudas, G., Hong, S. L., Potter, B. I., Calvignac-Spencer, S., Niatou-Singa, F. S., Tombolomako, T. B., Fuh-Neba, T., et al. (2021). Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.. Nat Commun, 12 (1) https://doi.org/10.1038/s41467-021-26055-8
Abstract
Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers.
Keywords
Africa, Central, Antibodies, Neutralizing, COVID-19, Europe, Humans, Immune Evasion, Mutation, Phylogeny, Phylogeography, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Travel
Identifiers
PMC8486757, 34599175
External DOI: https://doi.org/10.1038/s41467-021-26055-8
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330213
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