Rho GTPases in Skeletal Muscle Development and Homeostasis.
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Rodríguez-Fdez, S., & Bustelo, X. R. (2021). Rho GTPases in Skeletal Muscle Development and Homeostasis.. Cells, 10 (11) https://doi.org/10.3390/cells10112984
Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.
small G protein, RhoA, Rac1, Cdc42, guanosine nucleotide exchange factors, GTPase activating proteins, rock, pak, signaling, myogenesis, muscle mass, muscle regeneration, satellite cells, metabolism
Asociación Española Contra el Cáncer (GC16173472GARC)
Junta de Castilla y León (CSI252P18, CSI145P20, CLC-2017-01)
Fundación Ramón Areces (BEVP32P01S10090)
Spanish Ministry of Science and Innovation (RTI2018-096481-B-100, BES–2013–063573)
Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia of the Castilla-León autonomous government (CLC-2017-01)
External DOI: https://doi.org/10.3390/cells10112984
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330274