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dc.contributor.authorRodríguez-Fdez, Sonia
dc.contributor.authorBustelo, Xosé R
dc.date.accessioned2021-11-04T02:18:59Z
dc.date.available2021-11-04T02:18:59Z
dc.date.issued2021-11-02
dc.identifier.issn2073-4409
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330274
dc.description.abstractRho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.
dc.languageen
dc.publisherMDPI AG
dc.subjectsmall G protein
dc.subjectRhoA
dc.subjectRac1
dc.subjectCdc42
dc.subjectguanosine nucleotide exchange factors
dc.subjectGTPase activating proteins
dc.subjectrock
dc.subjectpak
dc.subjectsignaling
dc.subjectmyogenesis
dc.subjectmuscle mass
dc.subjectmuscle regeneration
dc.subjectsatellite cells
dc.subjectmetabolism
dc.titleRho GTPases in Skeletal Muscle Development and Homeostasis.
dc.typeArticle
dc.date.updated2021-11-04T02:18:58Z
prism.issueIdentifier11
prism.publicationNameCells
prism.volume10
dc.identifier.doi10.17863/CAM.77715
dcterms.dateAccepted2021-10-29
rioxxterms.versionofrecord10.3390/cells10112984
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidRodríguez-Fdez, Sonia [0000-0001-5369-2969]
dc.contributor.orcidBustelo, Xosé R [0000-0001-9398-6072]
dc.identifier.eissn2073-4409
pubs.funder-project-idAsociación Española Contra el Cáncer (GC16173472GARC)
pubs.funder-project-idJunta de Castilla y León (CSI252P18, CSI145P20, CLC-2017-01)
pubs.funder-project-idFundación Ramón Areces (BEVP32P01S10090)
pubs.funder-project-idSpanish Ministry of Science and Innovation (RTI2018-096481-B-100, BES–2013–063573)
pubs.funder-project-idCaixaBank (HR20-00164)
pubs.funder-project-idPrograma de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia of the Castilla-León autonomous government (CLC-2017-01)
cam.issuedOnline2021-11-02


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