The sooner the better: clinical and neural correlates of impulsive choice in Tourette disorder.
Authors
de Liege, Astrid
Klein, Yanica
Beranger, Benoit
Valabregue, Romain
Delorme, Cecile
Roze, Emmanuel
Fernandez-Egea, Emilio
Hartmann, Andreas
Worbe, Yulia
Publication Date
2021-11-03Journal Title
Transl Psychiatry
ISSN
2158-3188
Publisher
Springer Science and Business Media LLC
Volume
11
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Atkinson-Clement, C., de Liege, A., Klein, Y., Beranger, B., Valabregue, R., Delorme, C., Roze, E., et al. (2021). The sooner the better: clinical and neural correlates of impulsive choice in Tourette disorder.. Transl Psychiatry, 11 (1) https://doi.org/10.1038/s41398-021-01691-2
Description
Funder: Fondation pour la Recherche Médicale (Foundation for Medical Research in France); doi: https://doi.org/10.13039/501100002915
Abstract
Reward sensitivity has been suggested as one of the central pathophysiological mechanisms in Tourette disorder. However, the subjective valuation of a reward by introduction of delay has received little attention in Tourette disorder, even though it has been suggested as a trans-diagnostic feature of numerous neuropsychiatric disorders. We aimed to assess delay discounting in Tourette disorder and to identify its brain functional correlates. We evaluated delayed discounting and its brain functional correlates in a large group of 54 Tourette disorder patients and 31 healthy controls using a data-driven approach. We identified a subgroup of 29 patients with steeper reward discounting, characterised by a higher burden of impulse-control disorders and a higher level of general impulsivity compared to patients with normal behavioural performance or to controls. Reward discounting was underpinned by resting-state activity of a network comprising the orbito-frontal, cingulate, pre-supplementary motor area, temporal and insular cortices, as well as ventral striatum and hippocampus. Within this network, (i) lower connectivity of pre-supplementary motor area with ventral striatum predicted a higher impulsivity and a steeper reward discounting and (ii) a greater connectivity of pre-supplementary motor area with anterior insular cortex predicted steeper reward discounting and more severe tics. Overall, our results highlight the heterogeneity of the delayed reward processing in Tourette disorder, with steeper reward discounting being a marker of burden in impulsivity and impulse control disorders, and the pre-supplementary motor area being a hub region for the delay discounting, impulsivity and tic severity.
Keywords
Article, /631/477/2811, /692/699/476, /631/378, /59/36, /59/57, article
Sponsorship
Agence Nationale de la Recherche (French National Research Agency) (ANR-18-CE37-0008-01)
Identifiers
s41398-021-01691-2, 1691
External DOI: https://doi.org/10.1038/s41398-021-01691-2
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330294
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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