Cognitive interference processing in adults with childhood craniopharyngioma using functional magnetic resonance imaging.
Authors
Follin, Cecilia
Fjalldal, Sigridur
Hellerstedt, Robin
Mannfolk, Peter
Mårtensson, Johan
Sundgren, Pia
Erfurth, Eva Marie
Publication Date
2021-12Journal Title
Endocrine
ISSN
1355-008X
Publisher
Springer Science and Business Media LLC
Volume
74
Issue
3
Pages
714-722
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Svärd, D., Follin, C., Fjalldal, S., Hellerstedt, R., Mannfolk, P., Mårtensson, J., Sundgren, P., & et al. (2021). Cognitive interference processing in adults with childhood craniopharyngioma using functional magnetic resonance imaging.. Endocrine, 74 (3), 714-722. https://doi.org/10.1007/s12020-021-02824-9
Abstract
PURPOSE: To assess cognitive interference processing in adults with childhood craniopharyngioma (CP), with and without hypothalamic injury, respectively, in terms of behavioral performance and functional magnetic resonance imaging (fMRI) activity, using the multi-source interference task (MSIT). METHODS: Twenty-eight CP patients (median age 34.5 [29.0-39.5] years) were investigated at median 20.5 (16.3-28.8) years after treatment with surgical resection and in some cases additional radiotherapy (n = 10) and compared to 29 matched controls (median age 37.0 [32.5-42.0] years). The subjects performed the MSIT during fMRI acquisition and behavioral performance in terms of response times (ms) and accuracy performance (%) were recorded. RESULTS: The MSIT activated the cingulo-fronto-parietal (CFP) attention network in both CP patients and controls. No differences were found in behavioral performance nor fMRI activity between CP patients (interference effect 333.9 [287.3-367.1] ms and 3.1 [1.6-5.6]%, respectively) and controls (309.1 [276.4-361.0] ms and 2.6 [1.6-4.9]%). No differences were found in behavioral performance nor fMRI activity between the two subgroups with (332.0 [283.6-353.4] ms and 4.2 [2.3-5.7]%, respectively) and without hypothalamic injury (355.7 [293.7-388.7] ms and 2.1 [1.0-5.2]%, respectively), respectively, and controls. CONCLUSION: Adults with childhood CP performed cognitive interference processing equally well as controls and demonstrated no compensatory fMRI activity in the CFP attention network compared to controls. This was also true for the two subgroups with and without hypothalamic injury. The results can be useful to better characterize this condition, and to optimize treatment and support for these individuals.
Keywords
Original Article, Craniopharyngioma, Cognitive interference, fMRI, Multi-source interference task
Identifiers
s12020-021-02824-9, 2824
External DOI: https://doi.org/10.1007/s12020-021-02824-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330337
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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