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dc.contributor.authorTøien, Tiril
dc.contributor.authorHaglo, Håvard
dc.contributor.authorNyberg, Stian Kwak
dc.contributor.authorRao, Shalini Vasudev
dc.contributor.authorStunes, Astrid Kamilla
dc.contributor.authorMosti, Mats Peder
dc.contributor.authorWang, Eivind
dc.date.accessioned2021-11-05T16:31:43Z
dc.date.available2021-11-05T16:31:43Z
dc.date.issued2021-12
dc.date.submitted2021-03-25
dc.identifier.issn1439-6319
dc.identifier.others00421-021-04807-0
dc.identifier.other4807
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330341
dc.descriptionFunder: Norges Teknisk-Naturvitenskapelige Universitet; doi: http://dx.doi.org/10.13039/100009123
dc.descriptionFunder: Molde University College
dc.descriptionFunder: Molde University College - Specialized University in Logistics
dc.description.abstractINTRODUCTION: Maximal strength training (MST), performed with heavy loads (~ 90% of one repetition maximum; 1RM) and few repetitions, yields large improvements in efferent neural drive, skeletal muscle force production, and skeletal muscle efficiency. However, it is elusive whether neural adaptations following such high intensity strength training may be accompanied by alterations in energy-demanding muscular factors. METHODS: Sixteen healthy young males (24 ± 4 years) were randomized to MST 3 times per week for 8 weeks (n = 8), or a control group (CG; n = 8). Measurements included 1RM and rate of force development (RFD), and evoked potentials recordings (V-wave and H-reflex normalized to M-wave (M) in the soleus muscle) applied to assess efferent neural drive to maximally contracting skeletal muscle. Biopsies were obtained from vastus lateralis and analyzed by western blots and real-time PCR to investigate the relative protein expression and mRNA expression of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) 1 and SERCA2. RESULTS: Significant improvements in 1RM (17 ± 9%; p < 0.001) and early (0-100 ms), late (0-200 ms) and maximal RFD (31-53%; p < 0.01) were observed after MST, accompanied by increased maximal Vmax/Msup-ratio (9 ± 14%; p = 0.046), with no change in H-reflex to M-wave ratio. No changes were observed in the CG. No pre- to post-training differences were found in mRNA or protein expressions of SERCA1 and SERCA2 in either group. CONCLUSION: MST increased efferent neural drive to maximally contracting skeletal muscle, causing improved force production. No change was observed in SERCA expression, indicating that responses to high intensity strength training may predominantly be governed by neural adaptations.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectOriginal Article
dc.subjectStrength training
dc.subjectSERCA
dc.subjectEfferent neural drive
dc.subjectNeural adaptations
dc.titleMaximal strength training-induced increase in efferent neural drive is not reflected in relative protein expression of SERCA.
dc.typeArticle
dc.date.updated2021-11-05T16:31:42Z
prism.endingPage3430
prism.issueIdentifier12
prism.publicationNameEur J Appl Physiol
prism.startingPage3421
prism.volume121
dc.identifier.doi10.17863/CAM.77784
dcterms.dateAccepted2021-09-01
rioxxterms.versionofrecord10.1007/s00421-021-04807-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidTøien, Tiril [0000-0001-9632-3848]
dc.identifier.eissn1439-6327
cam.issuedOnline2021-09-08


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