Show simple item record

dc.contributor.authorGibson, Louise
dc.contributor.authorRibas, Maria Puig
dc.contributor.authorKemp, James
dc.contributor.authorRestif, Olivier
dc.contributor.authorSuu-Ire, Richard D
dc.contributor.authorWood, James LN
dc.contributor.authorCunningham, Andrew A
dc.date.accessioned2021-11-06T00:31:29Z
dc.date.available2021-11-06T00:31:29Z
dc.date.issued2021-08-20
dc.identifier.issn1999-4915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330377
dc.description.abstractBats have been identified as the natural hosts of several emerging zoonotic viruses, including paramyxoviruses, such as Hendra and Nipah viruses, that can cause fatal disease in humans. Recently, African fruit bats with populations that roost in or near urban areas have been shown to harbour a great diversity of paramyxoviruses, posing potential spillover risks to public health. Understanding the circulation of these viruses in their reservoir populations is essential to predict and prevent future emerging diseases. Here, we identify a high incidence of multiple paramyxoviruses in urine samples collected from a closed captive colony of circa 115 straw-coloured fruit bats (Eidolon helvum). The sequences detected have high nucleotide identities with those derived from free ranging African fruit bats and form phylogenetic clusters with the Henipavirus genus, Pararubulavirus genus and other unclassified paramyxoviruses. As this colony had been closed for 5 years prior to this study, these results indicate that within-host paramyxoviral persistence underlies the role of bats as reservoirs of these viruses.
dc.description.sponsorshipThis research was funded by Research England, the Royal Veterinary College, the Medical Research Council (grant number MR/P025226/1) and the Defense Advanced Research Projects Agency (DARPA) administered through Cooperative Agreement #D18AC00031-PREEMPT. JLNW and OR are funded by The Alborada Trust. AAC was part-funded by a Royal Society Wolfson Research Merit award.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHenipavirus
dc.subjectPararubulavirus
dc.subjectPteropodidae
dc.subjectchiroptera
dc.subjectlongitudinal study
dc.titlePersistence of Multiple Paramyxoviruses in a Closed Captive Colony of Fruit Bats (Eidolon helvum).
dc.typeArticle
prism.issueIdentifier8
prism.publicationNameViruses
prism.volume13
dc.identifier.doi10.17863/CAM.77820
dcterms.dateAccepted2021-08-16
rioxxterms.versionofrecord10.3390/v13081659
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-08-16
dc.contributor.orcidRestif, Olivier [0000-0001-9158-853X]
dc.contributor.orcidWood, James [0000-0002-0258-3188]
dc.identifier.eissn1999-4915
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/P025226/1)
cam.issuedOnline2021-08-20


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International