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dc.contributor.authorBurton, Nicholas O
dc.contributor.authorWillis, Alexandra
dc.contributor.authorFisher, Kinsey
dc.contributor.authorBraukmann, Fabian
dc.contributor.authorPrice, Jonathan
dc.contributor.authorStevens, Lewis
dc.contributor.authorBaugh, L Ryan
dc.contributor.authorReinke, Aaron
dc.contributor.authorMiska, Eric A
dc.date.accessioned2021-11-06T01:34:29Z
dc.date.available2021-11-06T01:34:29Z
dc.date.issued2021-10-08
dc.date.submitted2021-08-27
dc.identifier.other73425
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330387
dc.descriptionFunder: National Institutes of Health; FundRef: http://dx.doi.org/10.13039/100000002
dc.description.abstractDespite reports of parental exposure to stress promoting physiological adaptations in progeny in diverse organisms, there remains considerable debate over the significance and evolutionary conservation of such multigenerational effects. Here, we investigate four independent models of intergenerational adaptations to stress in Caenorhabditis elegans – bacterial infection, eukaryotic infection, osmotic stress, and nutrient stress – across multiple species. We found that all four intergenerational physiological adaptations are conserved in at least one other species, that they are stress -specific, and that they have deleterious tradeoffs in mismatched environments. By profiling the effects of parental bacterial infection and osmotic stress exposure on progeny gene expression across species, we established a core set of 587 genes that exhibited a greater than twofold intergenerational change in expression in response to stress in C. elegans and at least one other species, as well as a set of 37 highly conserved genes that exhibited a greater than twofold intergenerational change in expression in all four species tested. Furthermore, we provide evidence suggesting that presumed adaptive and deleterious intergenerational effects are molecularly related at the gene expression level. Lastly, we found that none of the effects we detected of these stresses on C. elegans F1 progeny gene expression persisted transgenerationally three generations after stress exposure. We conclude that intergenerational responses to stress play a substantial and evolutionarily conserved role in regulating animal physiology and that the vast majority of the effects of parental stress on progeny gene expression are reversible and not maintained transgenerationally.
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.subjectResearch Article
dc.subjectEvolutionary Biology
dc.subjectGenetics and Genomics
dc.subjecttransgenerational
dc.subjectP. vranovensis
dc.subjectosmotic stress
dc.subjectnutrient stress
dc.subjectN. parisii infection
dc.subjectintergenerational
dc.subjectC. elegans
dc.titleIntergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs
dc.typeArticle
dc.date.updated2021-11-06T01:34:27Z
prism.publicationNameeLife
prism.volume10
dc.identifier.doi10.17863/CAM.77830
dcterms.dateAccepted2021-09-27
rioxxterms.versionofrecord10.7554/elife.73425
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Tautz, Diethard
datacite.contributor.supervisorsenior_editor: Wittkopp, Patricia J
dc.contributor.orcidBurton, Nicholas O [0000-0002-5495-3988]
dc.contributor.orcidPrice, Jonathan [0000-0001-6554-5667]
dc.contributor.orcidStevens, Lewis [0000-0002-6075-8273]
dc.contributor.orcidBaugh, L Ryan [0000-0003-2148-5492]
dc.contributor.orcidReinke, Aaron [0000-0001-7612-5342]
dc.contributor.orcidMiska, Eric A [0000-0002-4450-576X]
dc.identifier.eissn2050-084X
pubs.funder-project-idCentre Trophoblast Research (Next Generation fellowship)
pubs.funder-project-idNational Institutes of Health (GM117408)
pubs.funder-project-idNatural Sciences and Engineering Research Council of Canada (Grant #522691522691)
pubs.funder-project-idAlfred P. Sloan Foundation (FG2019-12040)
pubs.funder-project-idCancer Research UK (C13474/A18583)
pubs.funder-project-idCancer Research UK (C6946/A14492)
pubs.funder-project-idWellcome Trust (104640/Z/14/Z)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)


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