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dc.contributor.authorGiorgi Rossi, Paolo
dc.contributor.authorDjuric, Olivera
dc.contributor.authorHélin, Valerie
dc.contributor.authorAstley, Susan
dc.contributor.authorMantellini, Paola
dc.contributor.authorNitrosi, Andrea
dc.contributor.authorHarkness, Elaine F
dc.contributor.authorGauthier, Emilien
dc.contributor.authorPuliti, Donella
dc.contributor.authorBalleyguier, Corinne
dc.contributor.authorBaron, Camille
dc.contributor.authorGilbert, Fiona J
dc.contributor.authorGrivegnée, André
dc.contributor.authorPattacini, Pierpaolo
dc.contributor.authorMichiels, Stefan
dc.contributor.authorDelaloge, Suzette
dc.date.accessioned2021-11-08T01:51:42Z
dc.date.available2021-11-08T01:51:42Z
dc.date.issued2021-10-06
dc.identifier.issn2045-2322
dc.identifier.otherPMC8494838
dc.identifier.other34615978
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330416
dc.description.abstractWe compared accuracy for breast cancer (BC) risk stratification of a new fully automated system (DenSeeMammo-DSM) for breast density (BD) assessment to a non-inferiority threshold based on radiologists' visual assessment. Pooled analysis was performed on 14,267 2D mammograms collected from women aged 48-55 years who underwent BC screening within three studies: RETomo, Florence study and PROCAS. BD was expressed through clinical Breast Imaging Reporting and Data System (BI-RADS) density classification. Women in BI-RADS D category had a 2.6 (95% CI 1.5-4.4) and a 3.6 (95% CI 1.4-9.3) times higher risk of incident and interval cancer, respectively, than women in the two lowest BD categories. The ability of DSM to predict risk of incident cancer was non-inferior to radiologists' visual assessment as both point estimate and lower bound of 95% CI (AUC 0.589; 95% CI 0.580-0.597) were above the predefined visual assessment threshold (AUC 0.571). AUC for interval (AUC 0.631; 95% CI 0.623-0.639) cancers was even higher. BD assessed with new fully automated method is positively associated with BC risk and is not inferior to radiologists' visual assessment. It is an even stronger marker of interval cancer, confirming an appreciable masking effect of BD that reduces mammography sensitivity.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2045-2322
dc.sourcenlmid: 101563288
dc.titleValidation of a new fully automated software for 2D digital mammographic breast density evaluation in predicting breast cancer risk.
dc.typeArticle
dc.date.updated2021-11-08T01:51:41Z
prism.issueIdentifier1
prism.publicationNameScientific reports
prism.volume11
dc.identifier.doi10.17863/CAM.77859
rioxxterms.versionofrecord10.1038/s41598-021-99433-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidDjuric, Olivera [0000-0002-8574-5938]
pubs.funder-project-idEuropean Union's Horizon 2020 research and innovation programme. (755394)
pubs.funder-project-idEuropean Union’s Horizon 2020 research and innovation programme. (755394)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International