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dc.contributor.authorBarnett, Helen Yvette
dc.contributor.authorVillar, Sofia
dc.contributor.authorGeys, Helena
dc.contributor.authorJaki, Thomas
dc.date.accessioned2021-11-08T14:23:45Z
dc.date.available2021-11-08T14:23:45Z
dc.date.issued2021-10-20
dc.date.submitted2020-07-15
dc.identifier.issn0006-341X
dc.identifier.otherbiom13581
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330429
dc.description.abstractThe most common objective for response-adaptive clinical trials is to seek to ensure that patients within a trial have a high chance of receiving the best treatment available by altering the chance of allocation on the basis of accumulating data. Approaches that yield good patient benefit properties suffer from low power from a frequentist perspective when testing for a treatment difference at the end of the study due to the high imbalance in treatment allocations. In this work we develop an alternative pairwise test for treatment difference on the basis of allocation probabilities of the covariate-adjusted response-adaptive randomization with forward-looking Gittins Index (CARA-FLGI) Rule for binary responses. The performance of the novel test is evaluated in simulations for two-armed studies and then its applications to multiarmed studies are illustrated. The proposed test has markedly improved power over the traditional Fisher exact test when this class of nonmyopic response adaptation is used. We also find that the test's power is close to the power of a Fisher exact test under equal randomization.
dc.languageen
dc.publisherWiley
dc.subjectBIOMETRIC METHODOLOGY
dc.subjectallocation probability
dc.subjectinference
dc.subjectnonmyopic
dc.subjectpower
dc.subjecttesting for superiority
dc.titleA novel statistical test for treatment differences in clinical trials using a response-adaptive forward-looking Gittins Index Rule.
dc.typeArticle
dc.date.updated2021-11-08T14:23:44Z
prism.publicationNameBiometrics
dc.identifier.doi10.17863/CAM.77872
dcterms.dateAccepted2021-09-30
rioxxterms.versionofrecord10.1111/biom.13581
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBarnett, Helen Yvette [0000-0001-7466-7033]
dc.contributor.orcidVillar, Sofia [0000-0001-7755-2637]
dc.contributor.orcidJaki, Thomas [0000-0002-1096-188X]
dc.identifier.eissn1541-0420
pubs.funder-project-idNIHR Academy (NIHRDH-SRF-2015-08-001)
pubs.funder-project-idMedical Research Council (MC_UU_00002/14)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
cam.issuedOnline2021-11-08


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