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dc.contributor.authorFrappaz, Didier
dc.contributor.authorDhall, Girish
dc.contributor.authorMurray, Matthew
dc.contributor.authorGoldman, Stuart
dc.contributor.authorFaure Conter, Cecile
dc.contributor.authorAllen, Jeffrey
dc.contributor.authorKortmann, Rolf Dieter
dc.contributor.authorHaas-Kogen, Daphne
dc.contributor.authorMorana, Giovanni
dc.contributor.authorFinlay, Jonathan
dc.contributor.authorNicholson, James C
dc.contributor.authorBartels, Ute
dc.contributor.authorSouweidane, Mark
dc.contributor.authorSchönberger, Stefan
dc.contributor.authorVasiljevic, Alexandre
dc.contributor.authorRobertson, Patricia
dc.contributor.authorAlbanese, Assunta
dc.contributor.authorAlapetite, Claire
dc.contributor.authorCzech, Thomas
dc.contributor.authorLau, Chin C
dc.contributor.authorWen, Patrick
dc.contributor.authorSchiff, David
dc.contributor.authorShaw, Dennis
dc.contributor.authorCalaminus, Gabriele
dc.contributor.authorBouffet, Eric
dc.date.accessioned2021-11-09T00:31:10Z
dc.date.available2021-11-09T00:31:10Z
dc.date.issued2022-04-01
dc.identifier.issn1522-8517
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330476
dc.description.abstractThe incidence of intracranial germ cell tumors (iGCT) is much lower in European and North American (E&NA) than in Asian population. However, E&NA cooperative groups have simultaneously developed with success treatment strategies with specific attention paid to long-term sequelae. Neurological sequelae may be reduced by establishing a diagnosis with an endoscopic biopsy and/or cerebrospinal fluid (CSF) and/or serum analysis, deferring the need to perform a radical surgery. Depending on markers and/or histological characteristics, patients are treated as either germinoma or non-germinomatous germ cell tumors (NGGCT). Metastatic disease is defined by a positive CSF cytology and/or distant drops in craniospinal MRI. The combination of surgery and/or chemotherapy and radiation therapy is tailored according to grouping and staging. With more than 90% 5-year event-free survival (EFS), localized germinomas can be managed without aggressive surgery, and benefit from chemotherapy followed by whole ventricular irradiation with local boost. Bifocal germinomas are treated as non-metastatic entities. Metastatic germinomas may be cured with craniospinal irradiation. With a 5-year EFS over 70%, NGGCT benefit from chemotherapy followed by delayed surgery in case of residual disease, and some form of radiotherapy. Future strategies will aim at decreasing long-term side effects while preserving high cure rates.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectBrain tumors
dc.subjectGerm Cell Tumor
dc.subjectGerminoma
dc.subjectNon-germinomatous germ cell tumor
dc.subjectadolescent and young adult
dc.titleEANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameNeuro Oncol
dc.identifier.doi10.17863/CAM.77920
dcterms.dateAccepted2021-10-26
rioxxterms.versionofrecord10.1093/neuonc/noab252
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2021-11-01
dc.contributor.orcidMurray, Matthew [0000-0002-4480-1147]
dc.contributor.orcidBartels, Ute [0000-0003-2112-5251]
dc.contributor.orcidAlbanese, Assunta [0000-0003-4051-6661]
dc.contributor.orcidCzech, Thomas [0000-0001-8112-2795]
dc.contributor.orcidBouffet, Eric [0000-0002-6832-6539]
dc.identifier.eissn1523-5866
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-11-01
cam.orpheus.success2021-11-08 - Embargo set during processing via Fast-track
rioxxterms.freetoread.startdate2022-11-01


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International