IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.
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Publication Date
2021-09-24Journal Title
Immunometabolism
ISSN
2084-6835
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
3
Issue
4
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Ryan, D., & Frezza, C. (2021). IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.. Immunometabolism, 3 (4) https://doi.org/10.20900/immunometab20210030
Abstract
Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo.
Keywords
Mitochondria, Metabolism, Immunotherapy, T cell, IL-10, Exhaustion
Sponsorship
Medical Research Council (MC_UU_12022/6)
Cancer Research UK (A27453)
European Research Council (819920)
Identifiers
PMC7611773, 34621543
External DOI: https://doi.org/10.20900/immunometab20210030
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330483
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