IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.

Ryan, Dylan; Frezza, Christian

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Authors

Ryan, Dylan

Frezza, Christian

Publication Date

2021-09-24

Journal Title

Immunometabolism

ISSN

2084-6835

Publisher

Ovid Technologies (Wolters Kluwer Health)

Volume

Issue

Language

eng

Type

Article

This Version

VoR

Metadata

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Citation

Ryan, D., & Frezza, C. (2021). IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.. Immunometabolism, 3 (4) https://doi.org/10.20900/immunometab20210030

Abstract

Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo.

Keywords

Mitochondria, Metabolism, Immunotherapy, T cell, IL-10, Exhaustion

Sponsorship

Medical Research Council (MC_UU_12022/6)

Cancer Research UK (A27453)

European Research Council (819920)

Identifiers

PMC7611773, 34621543

External DOI: https://doi.org/10.20900/immunometab20210030

This record's URL: https://www.repository.cam.ac.uk/handle/1810/330483

Rights

Attribution 4.0 International

Licence URL: https://creativecommons.org/licenses/by/4.0/

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