IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Ryan, Dylan
Frezza, Christian https://orcid.org/0000-0002-3293-7397
Abstract
Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo.
Description
Keywords
IL-10, T cell, exhaustion, immunotherapy, metabolism, mitochondria
Journal Title
Immunometabolism
Conference Name
Journal ISSN
2084-6835
2084-6835
2084-6835
Volume Title
3
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
Sponsorship
Medical Research Council (MC_UU_12022/6)
Cancer Research UK (A27453)
European Research Council (819920)
Cancer Research UK (A27453)
European Research Council (819920)