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dc.contributor.authorJeon, Sungwon
dc.contributor.authorBlazyte, Asta
dc.contributor.authorYoon, Changhan
dc.contributor.authorRyu, Hyojung
dc.contributor.authorJeon, Yeonsu
dc.contributor.authorBhak, Youngjune
dc.contributor.authorBolser, Dan
dc.contributor.authorManica, Andrea
dc.contributor.authorShin, Eun-Seok
dc.contributor.authorCho, Yun Sung
dc.contributor.authorKim, Byung Chul
dc.contributor.authorRyoo, Namhee
dc.contributor.authorChoi, Hansol
dc.contributor.authorBhak, Jong
dc.date.accessioned2021-11-10T00:30:39Z
dc.date.available2021-11-10T00:30:39Z
dc.date.issued2021-09-30
dc.identifier.issn1016-8478
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330520
dc.description.abstractCoronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones. One potential explanation for this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene, a key enzyme essential for viral infection and found a significant association between the COVID-19 case fatality rate and the V197M allele frequencies, using over 200,000 present-day and ancient genomic samples. East Asian countries have higher V197M allele frequencies than other regions, including European countries which correlates to their lower case fatality rates. Structural and energy calculation analysis of the V197M amino acid change showed that it destabilizes the TMPRSS2 protein, possibly negatively affecting its ACE2 and viral spike protein processing.
dc.format.mediumPrint
dc.languageeng
dc.publisherKorean Society for Molecular and Cellular Biology
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectHumans
dc.subjectSerine Endopeptidases
dc.subjectMortality
dc.subjectGene Frequency
dc.subjectPolymorphism, Single Nucleotide
dc.subjectModels, Molecular
dc.subjectAsian Continental Ancestry Group
dc.subjectEuropean Continental Ancestry Group
dc.subjectRepublic of Korea
dc.subjectCOVID-19
dc.titleRegional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates.
dc.typeArticle
prism.endingPage687
prism.issueIdentifier9
prism.publicationDate2021
prism.publicationNameMol Cells
prism.startingPage680
prism.volume44
dc.identifier.doi10.17863/CAM.77963
dcterms.dateAccepted2021-07-10
rioxxterms.versionofrecord10.14348/molcells.2021.2249
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-09
dc.contributor.orcidJeon, Sungwon [0000-0002-2729-9087]
dc.contributor.orcidBlazyte, Asta [0000-0001-7309-1482]
dc.contributor.orcidYoon, Changhan [0000-0003-0243-9853]
dc.contributor.orcidRyu, Hyojung [0000-0002-2276-850X]
dc.contributor.orcidJeon, Yeonsu [0000-0003-4560-4142]
dc.contributor.orcidBhak, Youngjune [0000-0002-9273-6984]
dc.contributor.orcidBolser, Dan [0000-0002-3991-0859]
dc.contributor.orcidManica, Andrea [0000-0003-1895-450X]
dc.contributor.orcidShin, Eun-Seok [0000-0002-9169-6968]
dc.contributor.orcidCho, Yun Sung [0000-0003-4490-8769]
dc.contributor.orcidKim, Byung Chul [0000-0002-4891-9679]
dc.contributor.orcidRyoo, Namhee [0000-0001-8383-709X]
dc.contributor.orcidChoi, Hansol [0000-0002-3653-1474]
dc.contributor.orcidBhak, Jong [0000-0002-4228-1299]
dc.identifier.eissn0219-1032
rioxxterms.typeJournal Article/Review


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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-ShareAlike 4.0 International