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dc.contributor.authorKonč, Juraj
dc.contributor.authorSabatino, Valerio
dc.contributor.authorJiménez-Moreno, Ester
dc.contributor.authorLatocheski, Eloah
dc.contributor.authorPérez, Laura Rodríguez
dc.contributor.authorDay, Jason
dc.contributor.authorDomingos, Josiel B
dc.contributor.authorLopes Bernardes, Goncalo
dc.date.accessioned2021-11-10T00:30:48Z
dc.date.available2021-11-10T00:30:48Z
dc.date.issued2022-02-14
dc.identifier.issn1433-7851
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330524
dc.description.abstractOwing to their bioorthogonality, transition metals have become very popular in the development of biocompatible bond-cleavage reactions. However, many approaches require design and synthesis of complex ligands or formulation of nanoparticles which often perform poorly in living cells. This work reports on a method for the generation of an active palladium species that triggers bond-cleaving reactions inside living cells. We utilized the water-soluble Na2PdCl4 as a simple source of Pd(II) which can be intracellularly reduced by sodium ascorbate to the active Pd(0) species. Once generated, Pd(0) triggers the cleavage of allyl ether and carbamate caging groups leading to the release of biologically active molecules. These findings do not only expand the toolbox of available bioorthogonal dissociative reactions but also provide an additional strategy for controlling the reactivity of Pd species involved in Pd-mediated bioorthogonal reactions.
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectCancer
dc.subjectPalladium
dc.subjectbioorthogonal
dc.subjectbond-cleavage
dc.subjectdecaging
dc.titleControlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.
dc.typeArticle
prism.publicationNameAngewandte Chemie International Edition
dc.identifier.doi10.17863/CAM.77967
dcterms.dateAccepted2021-11-05
rioxxterms.versionofrecord10.1002/anie.202113519
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-05
dc.contributor.orcidLopes Bernardes, Goncalo [0000-0001-6594-8917]
dc.identifier.eissn1521-3773
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (701473)
pubs.funder-project-idEuropean Research Council (676832)
cam.issuedOnline2021-11-05
cam.orpheus.success2021-11-09 - Embargo set during processing via Fast-track
rioxxterms.freetoread.startdate2022-11-05


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