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dc.contributor.authorQian, Pu
dc.contributor.authorCroll, Tristan
dc.contributor.authorSwainsbury, David JK
dc.contributor.authorCastro-Hartmann, Pablo
dc.contributor.authorMoriarty, Nigel W
dc.contributor.authorSader, Kasim
dc.contributor.authorHunter, C Neil
dc.date.accessioned2021-11-11T00:30:10Z
dc.date.available2021-11-11T00:30:10Z
dc.date.issued2021-09-17
dc.identifier.issn0264-6021
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330542
dc.description.abstractThe reaction centre light-harvesting 1 (RC-LH1) complex is the core functional component of bacterial photosynthesis. We determined the cryo-electron microscopy (cryo-EM) structure of the RC-LH1 complex from Rhodospirillum rubrum at 2.5 Å resolution, which reveals a unique monomeric bacteriochlorophyll with a phospholipid ligand in the gap between the RC and LH1 complexes. The LH1 complex comprises a circular array of 16 αβ-polypeptide subunits that completely surrounds the RC, with a preferential binding site for a quinone, designated QP, on the inner face of the encircling LH1 complex. Quinols, initially generated at the RC QB site, are proposed to transiently occupy the QP site prior to traversing the LH1 barrier and diffusing to the cytochrome bc1 complex. Thus, the QP site, which is analogous to other such sites in recent cryo-EM structures of RC-LH1 complexes, likely reflects a general mechanism for exporting quinols from the RC-LH1 complex.
dc.format.mediumPrint
dc.languageeng
dc.publisherPortland Press Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleCryo-EM structure of the Rhodospirillum rubrum RC-LH1 complex at 2.5 Å.
dc.typeArticle
prism.endingPage3263
prism.issueIdentifier17
prism.publicationDate2021
prism.publicationNameBiochem J
prism.startingPage3253
prism.volume478
dc.identifier.doi10.17863/CAM.77986
dcterms.dateAccepted2021-08-17
rioxxterms.versionofrecord10.1042/BCJ20210511
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-09
dc.contributor.orcidCroll, Tristan [0000-0002-3514-8377]
dc.contributor.orcidHunter, C Neil [0000-0003-2533-9783]
dc.identifier.eissn1470-8728
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (209407/Z/17/Z)
cam.issuedOnline2021-09-07


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International