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dc.contributor.authorOhlmeier, Laura
dc.contributor.authorNannoni, Stefania
dc.contributor.authorPallucca, Claudia
dc.contributor.authorBrown, Robin
dc.contributor.authorLoubiere, Laurence
dc.contributor.authorMarkus, Hugh
dc.contributor.authorDNA Lacunar 2 Investigators
dc.date.accessioned2021-11-16T00:30:55Z
dc.date.available2021-11-16T00:30:55Z
dc.date.issued2022-01-05
dc.identifier.issn1747-4930
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330665
dc.description.abstractBACKGROUND: Small vessel disease (SVD) is associated with vascular cognitive impairment (VCI) but why VCI occurs in some, but not other patients, is uncertain. We determined the prevalence of, and risk factors for, VCI in a large cohort of patients with lacunar stroke. METHODS: Participants with magnetic resonance imaging (MRI)-confirmed lacunar stroke were recruited in the multicenter DNA Lacunar 2 study and compared with healthy controls. A logistic regression model was used to determine which vascular risk factors and MRI parameters were independent predictors of VCI, assessed using the Brief Memory and Executive Test (BMET). RESULTS: A total of 912 lacunar stroke patients and 425 controls were included, with mean (SD) age of 64.6 (12.26) and 64.7 (12.29) years, respectively. VCI was detected in 38.8% lacunar patients and 13.4% controls. In a logistic regression model, diabetes mellitus (odds ratio (OR) = 1.98 (95% confidence interval (CI) = 1.40-2.80), p < 0.001) and higher body mass index (BMI) (OR = 1.03 (95% CI = 1.00-1.05), p = 0.029) were independently associated with increased risk of VCI, and years of full-time education with lower risk (OR = 0.92 (95% CI = 0.86-0.99), p = 0.018). When entering both lacune count and white matter hyperintensity (WMH) in the same logistic regression model, only WMH grade was significantly associated with VCI (OR = 1.46 (95% CI = 1.24-1.72), p < 0.001). CONCLUSION: VCI is common in lacunar stroke patients, affecting almost 40%. This prevalence suggests that it should be routinely screened for in clinical practice. Risk factors for VCI in patients with lacunar stroke include diabetes mellitus, depressive symptoms, higher BMI, and WMH severity, while education is protective.
dc.publisherSAGE Publications
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titlePrevalence of, and risk factors for, cognitive impairment in lacunar stroke.
dc.typeArticle
prism.publicationNameInt J Stroke
dc.identifier.doi10.17863/CAM.78110
dcterms.dateAccepted2021-11-10
rioxxterms.versionofrecord10.1177/17474930211064965
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-10
dc.contributor.orcidOhlmeier, Laura [0000-0003-4791-1015]
dc.contributor.orcidNannoni, Stefania [0000-0002-1825-1874]
dc.contributor.orcidBrown, Robin [0000-0003-0431-7841]
dc.contributor.orcidMarkus, Hugh [0000-0002-9794-5996]
dc.identifier.eissn1747-4949
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (RG/16/4/32218)
pubs.funder-project-idStroke Association (PPA 2015/02)
pubs.funder-project-idMedical Research Council (MR/N026896/1)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
cam.issuedOnline2022-01-05
cam.orpheus.successTue Feb 01 19:02:15 GMT 2022 - Embargo updated
cam.orpheus.counter1
rioxxterms.freetoread.startdate2022-01-05


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