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dc.contributor.authorFazakerley, Daniel J
dc.contributor.authorFritzen, Andreas M
dc.contributor.authorNelson, Marin E
dc.contributor.authorThorius, Ida H
dc.contributor.authorCooke, Kristen C
dc.contributor.authorHumphrey, Sean J
dc.contributor.authorCooney, Gregory J
dc.contributor.authorJames, David E
dc.date.accessioned2021-11-17T00:30:15Z
dc.date.available2021-11-17T00:30:15Z
dc.date.issued2019-01-20
dc.identifier.issn2331-8325
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330681
dc.description.abstractInsulin resistance is a pathophysiological state defined by impaired responses to insulin and is a risk factor for several metabolic diseases, most notably type 2 diabetes. Insulin resistance occurs in insulin target tissues including liver, adipose and skeletal muscle. Methods such as insulin tolerance tests and hyperinsulinaemic-euglycaemic clamps permit assessment of insulin responses in specific tissues and allow the study of the progression and causes of insulin resistance. Here we detail a protocol for assessing insulin action in adipose and muscle tissues in anesthetized mice administered with insulin intravenously.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherBio-Protocol, LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleInsulin Tolerance Test under Anaesthesia to Measure Tissue-specific Insulin-stimulated Glucose Disposal.
dc.typeArticle
prism.issueIdentifier2
prism.publicationDate2019
prism.publicationNameBio Protoc
prism.startingPagee3146
prism.volume9
dc.identifier.doi10.17863/CAM.78126
dcterms.dateAccepted2018-12-24
rioxxterms.versionofrecord10.21769/BioProtoc.3146
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01-20
dc.contributor.orcidFazakerley, Daniel [0000-0001-8241-2903]
dc.identifier.eissn2331-8325
rioxxterms.typeJournal Article/Review
cam.issuedOnline2019-01-20


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International