Show simple item record

dc.contributor.authorMerlini, Elisa
dc.contributor.authorColeman, Michael P
dc.contributor.authorLoreto, Andrea
dc.date.accessioned2021-11-17T00:30:40Z
dc.date.available2021-11-17T00:30:40Z
dc.date.issued2022-01
dc.identifier.issn0166-2236
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330692
dc.description.abstractMitochondrial failure has long been associated with programmed axon death (Wallerian degeneration, WD), a widespread and potentially preventable mechanism of axon degeneration. While early findings in axotomised axons indicated that mitochondria are involved during the execution steps of this pathway, recent studies suggest that in addition, mitochondrial dysfunction can initiate programmed axon death without physical injury. As mitochondrial dysfunction is associated with disorders involving early axon loss, including Parkinson's disease, peripheral neuropathies, and multiple sclerosis, the findings that programmed axon death is activated by mitochondrial impairment could indicate the involvement of druggable mechanisms whose disruption may protect axons in such diseases. Here, we review the latest developments linking mitochondrial dysfunction to programmed axon death and discuss their implications for injury and disease.
dc.publisherElsevier BV
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleMitochondrial dysfunction as a trigger of programmed axon death.
dc.typeArticle
prism.publicationNameTrends Neurosci
dc.identifier.doi10.17863/CAM.78137
dcterms.dateAccepted2021-10-29
rioxxterms.versionofrecord10.1016/j.tins.2021.10.014
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.contributor.orcidColeman, Michael [0000-0002-9354-532X]
dc.contributor.orcidLoreto, Andrea [0000-0001-6535-6436]
dc.identifier.eissn1878-108X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (210904/Z/18/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/S009582/1)
cam.issuedOnline2021-11-29
cam.orpheus.successTue Feb 01 19:02:15 GMT 2022 - Embargo updated
cam.orpheus.counter1
rioxxterms.freetoread.startdate2023-01-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record