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dc.contributor.authorPoort, Jasper
dc.contributor.authorWilmes, Katharina A
dc.contributor.authorBlot, Antonin
dc.contributor.authorChadwick, Angus
dc.contributor.authorSahani, Maneesh
dc.contributor.authorClopath, Claudia
dc.contributor.authorMrsic-Flogel, Thomas D
dc.contributor.authorHofer, Sonja B
dc.contributor.authorKhan, Adil G
dc.date.accessioned2021-11-19T00:30:30Z
dc.date.available2021-11-19T00:30:30Z
dc.date.issued2022-02-16
dc.identifier.issn0896-6273
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330748
dc.description.abstractSelectivity of cortical neurons for sensory stimuli can increase across days as animals learn their behavioral relevance and across seconds when animals switch attention. While both phenomena occur in the same circuit, it is unknown whether they rely on similar mechanisms. We imaged primary visual cortex as mice learned a visual discrimination task and subsequently performed an attention switching task. Selectivity changes due to learning and attention were uncorrelated in individual neurons. Selectivity increases after learning mainly arose from selective suppression of responses to one of the stimuli but from selective enhancement and suppression during attention. Learning and attention differentially affected interactions between excitatory and PV, SOM, and VIP inhibitory cells. Circuit modeling revealed that cell class-specific top-down inputs best explained attentional modulation, while reorganization of local functional connectivity accounted for learning-related changes. Thus, distinct mechanisms underlie increased discriminability of relevant sensory stimuli across longer and shorter timescales.
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLearning and attention increase visual response selectivity through distinct mechanisms.
dc.typeArticle
prism.publicationNameNeuron
dc.identifier.doi10.17863/CAM.78189
dcterms.dateAccepted2021-11-15
rioxxterms.versionofrecord10.1016/j.neuron.2021.11.016
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-15
dc.contributor.orcidPoort, Jasper [0000-0001-6306-4042]
dc.identifier.eissn1097-4199
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (211258/Z/18/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N019008/1)
cam.orpheus.successTue Feb 01 19:02:18 GMT 2022 - Embargo updated
cam.orpheus.counter1
rioxxterms.freetoread.startdate2022-12-09


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International