The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease.
Carrillo Félez, Eva
J Clin Med
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Rujeedawa, T., Carrillo Félez, E., Clare, I., Fortea, J., Strydom, A., Rebillat, A., Coppus, A., et al. (2021). The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease.. J Clin Med, 10 (19) https://doi.org/10.3390/jcm10194582
The purpose of this review is to compare and highlight the clinical and pathological aspects of genetic versus acquired Alzheimer's disease: Down syndrome-associated Alzheimer's disease in (DSAD) and Autosomal Dominant Alzheimer's disease (ADAD) are compared with the late-onset form of the disease (LOAD). DSAD and ADAD present in a younger population and are more likely to manifest with non-amnestic (such as dysexecutive function features) in the prodromal phase or neurological features (such as seizures and paralysis) especially in ADAD. The very large variety of mutations associated with ADAD explains the wider range of phenotypes. In the LOAD, age-associated comorbidities explain many of the phenotypic differences.
Neuropathology, Down syndrome, Clinical features, Late-onset Alzheimer’s Disease, Autosomal Dominant Alzheimer ’S Disease
Fondation Jérôme Lejeune (Horizon21)
External DOI: https://doi.org/10.3390/jcm10194582
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330809
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/