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dc.contributor.authorRujeedawa, Tanzil
dc.contributor.authorCarrillo Félez, Eva
dc.contributor.authorClare, Isabel
dc.contributor.authorFortea, Juan
dc.contributor.authorStrydom, Andre
dc.contributor.authorRebillat, Anne-Sophie
dc.contributor.authorCoppus, Antonia
dc.contributor.authorLevin, Johannes
dc.contributor.authorZaman, Shahid
dc.date.accessioned2021-11-22T14:37:21Z
dc.date.available2021-11-22T14:37:21Z
dc.date.issued2021-10-03
dc.identifier.issn2077-0383
dc.identifier.otherPMC8509365
dc.identifier.other34640600
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330809
dc.description.abstractThe purpose of this review is to compare and highlight the clinical and pathological aspects of genetic versus acquired Alzheimer's disease: Down syndrome-associated Alzheimer's disease in (DSAD) and Autosomal Dominant Alzheimer's disease (ADAD) are compared with the late-onset form of the disease (LOAD). DSAD and ADAD present in a younger population and are more likely to manifest with non-amnestic (such as dysexecutive function features) in the prodromal phase or neurological features (such as seizures and paralysis) especially in ADAD. The very large variety of mutations associated with ADAD explains the wider range of phenotypes. In the LOAD, age-associated comorbidities explain many of the phenotypic differences.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2077-0383
dc.sourcenlmid: 101606588
dc.subjectNeuropathology
dc.subjectDown syndrome
dc.subjectClinical features
dc.subjectLate-onset Alzheimer’s Disease
dc.subjectAutosomal Dominant Alzheimer ’S Disease
dc.titleThe Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease.
dc.typeArticle
dc.date.updated2021-11-22T14:37:21Z
prism.issueIdentifier19
prism.publicationNameJ Clin Med
prism.volume10
dc.identifier.doi10.17863/CAM.78252
dcterms.dateAccepted2021-09-28
rioxxterms.versionofrecord10.3390/jcm10194582
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidClare, Isabel [0000-0002-5385-008X]
dc.contributor.orcidRebillat, Anne-Sophie [0000-0003-1995-9177]
dc.contributor.orcidZaman, Shahid [0000-0003-1639-6014]
dc.identifier.eissn2077-0383
pubs.funder-project-idFondation Jérôme Lejeune (Horizon21)
cam.issuedOnline2021-10-03


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International