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dc.contributor.authorWaters, Ella
dc.contributor.authorPucci, Perla
dc.contributor.authorHirst, Mark
dc.contributor.authorChapman, Simon
dc.contributor.authorWang, Yuzhuo
dc.contributor.authorCrea, Francesco
dc.contributor.authorHeath, Christopher J
dc.date.accessioned2021-11-22T14:38:16Z
dc.date.available2021-11-22T14:38:16Z
dc.date.issued2021-11
dc.date.submitted2021-02-22
dc.identifier.issn1750-1911
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330821
dc.description.abstractLong noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. HAR1 is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, HAR1A and HAR1B. Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study.
dc.languageen
dc.publisherFuture Medicine Ltd
dc.rightsEmbargo: starts 2021-10-22, ends 2022-10-22, duration 12 months from publication.
dc.subjectReview
dc.subjectDNA conservation
dc.subjectgenetic evolution
dc.subjectHAR1
dc.subjectlncRNAs
dc.subjectmolecular structure
dc.titleHAR1: an insight into lncRNA genetic evolution.
dc.typeArticle
dc.date.updated2021-11-22T14:38:15Z
prism.endingPage1843
prism.issueIdentifier22
prism.publicationNameEpigenomics
prism.startingPage1831
prism.volume13
dc.identifier.doi10.17863/CAM.78264
dcterms.dateAccepted2021-10-01
rioxxterms.versionofrecord10.2217/epi-2021-0069
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://www.future-science-group.com/archiving
rioxxterms.licenseref.startdate2022-10-22
dc.contributor.orcidWaters, Ella [0000-0003-4600-3648]
dc.contributor.orcidPucci, Perla [0000-0003-1264-3487]
dc.contributor.orcidHirst, Mark [0000-0003-3851-9740]
dc.contributor.orcidChapman, Simon [0000-0001-7680-5049]
dc.contributor.orcidWang, Yuzhuo [0000-0002-9749-8591]
dc.contributor.orcidCrea, Francesco [0000-0002-4903-2973]
dc.contributor.orcidHeath, Christopher J [0000-0003-3485-7128]
dc.identifier.eissn1750-192X
rioxxterms.freetoread.startdate2022-10-22


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