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dc.contributor.authorSeo, Mikyung Kelly
dc.contributor.authorStrong, Mark
dc.date.accessioned2021-11-22T14:44:58Z
dc.date.available2021-11-22T14:44:58Z
dc.date.issued2021-12
dc.identifier.issn1170-7690
dc.identifier.others40273-021-01069-8
dc.identifier.other1069
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330881
dc.description.abstractDespite the increasing number of potential biomarkers identified in laboratories and reported in much literature, the adoption of biomarkers routinely available in clinical practice to inform treatment decisions is very limited. Reimbursement decisions for new health technologies are often informed by economic evaluations; however, economic evaluations of diagnostics/testing technologies, such as companion biomarker tests, are far less frequently reported than drugs. Furthermore, few countries provide the health economic evaluation methods guide specific to co-dependent technologies such as companion diagnostics or precision medicines. Therefore, this paper aims to guide the process of the development of cost-effectiveness models of cancer biomarkers for targeted therapies, focusing on companion diagnostics. This tutorial paper provides practical guidance on how to conduct economic evaluations of cancer biomarkers and how to model the characteristics of the biomarker tests as part of the value for money of corresponding targeted therapies. This paper presents a brief introduction to the methods and data requirements, a step-by-step guide to constructing a health economic model of companion cancer biomarkers, and a discussion of issues that arise in their application to healthcare decision making. This practical guidance is provided in R, and worked examples are provided in this paper with R codes in the accompanying electronic supplementary material.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectPractical Application
dc.titleA Practical Guide to Modeling and Conducting a Cost-Effectiveness Analysis of Companion Biomarker Tests for Targeted Therapies Using R: Tutorial Paper.
dc.typeArticle
dc.date.updated2021-11-22T14:44:57Z
prism.endingPage1381
prism.issueIdentifier12
prism.publicationNamePharmacoeconomics
prism.startingPage1373
prism.volume39
dc.identifier.doi10.17863/CAM.78324
dcterms.dateAccepted2021-07-13
rioxxterms.versionofrecord10.1007/s40273-021-01069-8
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.contributor.orcidSeo, Mikyung Kelly [0000-0003-4746-2264]
dc.identifier.eissn1179-2027
cam.issuedOnline2021-08-20


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