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dc.contributor.authorGomez, Alwyn
dc.contributor.authorSainbhi, Amanjyot Singh
dc.contributor.authorFroese, Logan
dc.contributor.authorBatson, Carleen
dc.contributor.authorAlizadeh, Arsalan
dc.contributor.authorMendelson, Asher A
dc.contributor.authorZeiler, Frederick A
dc.date.accessioned2021-11-22T14:48:02Z
dc.date.available2021-11-22T14:48:02Z
dc.date.issued2021
dc.date.submitted2021-06-02
dc.identifier.issn1663-9812
dc.identifier.other719501
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330914
dc.description.abstractMultimodal monitoring has been gaining traction in the critical care of patients following traumatic brain injury (TBI). Through providing a deeper understanding of the individual patient's comprehensive physiologic state, or "physiome," following injury, these methods hold the promise of improving personalized care and advancing precision medicine. One of the modalities being explored in TBI care is near-infrared spectroscopy (NIRS), given it's non-invasive nature and ability to interrogate microvascular and tissue oxygen metabolism. In this narrative review, we begin by discussing the principles of NIRS technology, including spatially, frequency, and time-resolved variants. Subsequently, the applications of NIRS in various phases of clinical care following TBI are explored. These applications include the pre-hospital, intraoperative, neurocritical care, and outpatient/rehabilitation setting. The utility of NIRS to predict functional outcomes and evaluate dysfunctional cerebrovascular reactivity is also discussed. Finally, future applications and potential advancements in NIRS-based physiologic monitoring of TBI patients are presented, with a description of the potential integration with other omics biomarkers.
dc.languageen
dc.publisherFrontiers Media SA
dc.subjectPharmacology
dc.subjecttraumatic brain injury
dc.subjectnear-infrared spectroscopy
dc.subjectcerebrovascular reactivity
dc.subjectmulti-modal monitoring
dc.subjectprecision medicine
dc.titleNear Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions.
dc.typeArticle
dc.date.updated2021-11-22T14:48:01Z
prism.publicationNameFront Pharmacol
prism.volume12
dc.identifier.doi10.17863/CAM.78357
dcterms.dateAccepted2021-10-22
rioxxterms.versionofrecord10.3389/fphar.2021.719501
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1663-9812
cam.issuedOnline2021-11-05


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