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dc.contributor.authorOstaszewski, Marek
dc.contributor.authorNiarakis, Anna
dc.contributor.authorMazein, Alexander
dc.contributor.authorKuperstein, Inna
dc.contributor.authorPhair, Robert
dc.contributor.authorOrta-Resendiz, Aurelio
dc.contributor.authorSingh, Vidisha
dc.contributor.authorAghamiri, Sara Sadat
dc.contributor.authorAcencio, Marcio Luis
dc.contributor.authorGlaab, Enrico
dc.contributor.authorRuepp, Andreas
dc.contributor.authorFobo, Gisela
dc.contributor.authorMontrone, Corinna
dc.contributor.authorBrauner, Barbara
dc.contributor.authorFrishman, Goar
dc.contributor.authorMonraz Gómez, Luis Cristóbal
dc.contributor.authorSomers, Julia
dc.contributor.authorHoch, Matti
dc.contributor.authorKumar Gupta, Shailendra
dc.contributor.authorScheel, Julia
dc.contributor.authorBorlinghaus, Hanna
dc.contributor.authorCzauderna, Tobias
dc.contributor.authorSchreiber, Falk
dc.contributor.authorMontagud, Arnau
dc.contributor.authorPonce de Leon, Miguel
dc.contributor.authorFunahashi, Akira
dc.contributor.authorHiki, Yusuke
dc.contributor.authorHiroi, Noriko
dc.contributor.authorYamada, Takahiro G
dc.contributor.authorDräger, Andreas
dc.contributor.authorRenz, Alina
dc.contributor.authorNaveez, Muhammad
dc.contributor.authorBocskei, Zsolt
dc.contributor.authorMessina, Francesco
dc.contributor.authorBörnigen, Daniela
dc.contributor.authorFergusson, Liam
dc.contributor.authorConti, Marta
dc.contributor.authorRameil, Marius
dc.contributor.authorNakonecnij, Vanessa
dc.contributor.authorVanhoefer, Jakob
dc.contributor.authorSchmiester, Leonard
dc.contributor.authorWang, Muying
dc.contributor.authorAckerman, Emily E
dc.contributor.authorShoemaker, Jason E
dc.contributor.authorZucker, Jeremy
dc.contributor.authorOxford, Kristie
dc.contributor.authorTeuton, Jeremy
dc.contributor.authorKocakaya, Ebru
dc.contributor.authorSummak, Gökçe Yağmur
dc.contributor.authorHanspers, Kristina
dc.contributor.authorKutmon, Martina
dc.contributor.authorCoort, Susan
dc.contributor.authorEijssen, Lars
dc.contributor.authorEhrhart, Friederike
dc.contributor.authorRex, Devasahayam Arokia Balaya
dc.contributor.authorSlenter, Denise
dc.contributor.authorMartens, Marvin
dc.contributor.authorPham, Nhung
dc.contributor.authorHaw, Robin
dc.contributor.authorJassal, Bijay
dc.contributor.authorMatthews, Lisa
dc.contributor.authorOrlic-Milacic, Marija
dc.contributor.authorSenff Ribeiro, Andrea
dc.contributor.authorRothfels, Karen
dc.contributor.authorShamovsky, Veronica
dc.contributor.authorStephan, Ralf
dc.contributor.authorSevilla, Cristoffer
dc.contributor.authorVarusai, Thawfeek
dc.contributor.authorRavel, Jean-Marie
dc.contributor.authorFraser, Rupsha
dc.contributor.authorOrtseifen, Vera
dc.contributor.authorMarchesi, Silvia
dc.contributor.authorGawron, Piotr
dc.contributor.authorSmula, Ewa
dc.contributor.authorHeirendt, Laurent
dc.contributor.authorSatagopam, Venkata
dc.contributor.authorWu, Guanming
dc.contributor.authorRiutta, Anders
dc.contributor.authorGolebiewski, Martin
dc.contributor.authorOwen, Stuart
dc.contributor.authorGoble, Carole
dc.contributor.authorHu, Xiaoming
dc.contributor.authorOverall, Rupert W
dc.contributor.authorMaier, Dieter
dc.contributor.authorBauch, Angela
dc.contributor.authorGyori, Benjamin M
dc.contributor.authorBachman, John A
dc.contributor.authorVega, Carlos
dc.contributor.authorGrouès, Valentin
dc.contributor.authorVazquez, Miguel
dc.contributor.authorPorras, Pablo
dc.contributor.authorLicata, Luana
dc.contributor.authorIannuccelli, Marta
dc.contributor.authorSacco, Francesca
dc.contributor.authorNesterova, Anastasia
dc.contributor.authorYuryev, Anton
dc.contributor.authorde Waard, Anita
dc.contributor.authorTurei, Denes
dc.contributor.authorLuna, Augustin
dc.contributor.authorBabur, Ozgun
dc.contributor.authorSoliman, Sylvain
dc.contributor.authorValdeolivas, Alberto
dc.contributor.authorEsteban-Medina, Marina
dc.contributor.authorPeña-Chilet, Maria
dc.contributor.authorRian, Kinza
dc.contributor.authorHelikar, Tomáš
dc.contributor.authorPuniya, Bhanwar Lal
dc.contributor.authorModos, Dezso
dc.contributor.authorTreveil, Agatha
dc.contributor.authorOlbei, Marton
dc.contributor.authorDe Meulder, Bertrand
dc.contributor.authorBallereau, Stephane
dc.contributor.authorDugourd, Aurélien
dc.contributor.authorNaldi, Aurélien
dc.contributor.authorNoël, Vincent
dc.contributor.authorCalzone, Laurence
dc.contributor.authorSander, Chris
dc.contributor.authorDemir, Emek
dc.contributor.authorKorcsmaros, Tamas
dc.contributor.authorFreeman, Tom C
dc.contributor.authorAugé, Franck
dc.contributor.authorBeckmann, Jacques S
dc.contributor.authorHasenauer, Jan
dc.contributor.authorWolkenhauer, Olaf
dc.contributor.authorWilighagen, Egon L
dc.contributor.authorPico, Alexander R
dc.contributor.authorEvelo, Chris T
dc.contributor.authorGillespie, Marc E
dc.contributor.authorStein, Lincoln D
dc.contributor.authorHermjakob, Henning
dc.contributor.authorD'Eustachio, Peter
dc.contributor.authorSaez-Rodriguez, Julio
dc.contributor.authorDopazo, Joaquin
dc.contributor.authorValencia, Alfonso
dc.contributor.authorKitano, Hiroaki
dc.contributor.authorBarillot, Emmanuel
dc.contributor.authorAuffray, Charles
dc.contributor.authorBalling, Rudi
dc.contributor.authorSchneider, Reinhard
dc.date.accessioned2021-11-22T14:49:37Z
dc.date.available2021-11-22T14:49:37Z
dc.date.issued2021-10-01
dc.identifier.issn1744-4292
dc.identifier.otherPMC8524328
dc.identifier.other34664389
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330933
dc.descriptionFunder: Bundesministerium für Bildung und Forschung
dc.descriptionFunder: Bundesministerium für Bildung und Forschung (BMBF)
dc.description.abstractWe need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1744-4292
dc.sourcenlmid: 101235389
dc.subjectSystems Biomedicine
dc.subjectOmics Data Analysis
dc.subjectComputable Knowledge Repository
dc.subjectLarge-scale Biocuration
dc.subjectOpen Access Community Effort
dc.titleCOVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.
dc.typeArticle
dc.date.updated2021-11-22T14:49:36Z
prism.issueIdentifier10
prism.publicationNameMolecular systems biology
prism.volume17
dc.identifier.doi10.17863/CAM.78376
rioxxterms.versionofrecord10.15252/msb.202110387
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidOstaszewski, Marek [0000-0003-1473-370X]
dc.contributor.orcidNiarakis, Anna [0000-0002-9687-7426]
dc.contributor.orcidMazein, Alexander [0000-0001-7137-4171]
dc.contributor.orcidKuperstein, Inna [0000-0001-8086-8915]
dc.contributor.orcidPhair, Robert [0000-0001-7979-2386]
dc.contributor.orcidOrta-Resendiz, Aurelio [0000-0002-6632-883X]
dc.contributor.orcidSingh, Vidisha [0000-0002-3250-6669]
dc.contributor.orcidAghamiri, Sara Sadat [0000-0003-4440-7059]
dc.contributor.orcidAcencio, Marcio Luis [0000-0002-8278-240X]
dc.contributor.orcidGlaab, Enrico [0000-0003-3977-7469]
dc.contributor.orcidRuepp, Andreas [0000-0003-1705-3515]
dc.contributor.orcidSomers, Julia [0000-0001-9489-2246]
dc.contributor.orcidHoch, Matti [0000-0002-2486-0246]
dc.contributor.orcidKumar Gupta, Shailendra [0000-0002-3470-3260]
dc.contributor.orcidScheel, Julia [0000-0002-0034-7755]
dc.contributor.orcidCzauderna, Tobias [0000-0002-1788-9593]
dc.contributor.orcidMontagud, Arnau [0000-0002-7696-1241]
dc.contributor.orcidPonce de Leon, Miguel [0000-0002-7496-844X]
dc.contributor.orcidFunahashi, Akira [0000-0003-0605-239X]
dc.contributor.orcidHiki, Yusuke [0000-0001-6955-3867]
dc.contributor.orcidHiroi, Noriko [0000-0002-0214-373X]
dc.contributor.orcidYamada, Takahiro G [0000-0002-1665-1778]
dc.contributor.orcidDräger, Andreas [0000-0002-1240-5553]
dc.contributor.orcidRenz, Alina [0000-0003-3851-9978]
dc.contributor.orcidNaveez, Muhammad [0000-0003-2437-2055]
dc.contributor.orcidBocskei, Zsolt [0000-0002-6105-2504]
dc.contributor.orcidMessina, Francesco [0000-0001-8076-7217]
dc.contributor.orcidBörnigen, Daniela [0000-0002-7370-2033]
dc.contributor.orcidRameil, Marius [0000-0002-5298-9995]
dc.contributor.orcidVanhoefer, Jakob [0000-0002-3451-1701]
dc.contributor.orcidSchmiester, Leonard [0000-0001-7946-3232]
dc.contributor.orcidAckerman, Emily E [0000-0003-0735-7152]
dc.contributor.orcidShoemaker, Jason E [0000-0003-3315-7103]
dc.contributor.orcidZucker, Jeremy [0000-0002-7276-9009]
dc.contributor.orcidOxford, Kristie [0000-0002-8125-1391]
dc.contributor.orcidTeuton, Jeremy [0000-0002-7703-8870]
dc.contributor.orcidKocakaya, Ebru [0000-0002-8347-3393]
dc.contributor.orcidSummak, Gökçe Yağmur [0000-0001-6274-3385]
dc.contributor.orcidHanspers, Kristina [0000-0001-5410-599X]
dc.contributor.orcidKutmon, Martina [0000-0002-7699-8191]
dc.contributor.orcidCoort, Susan [0000-0003-1224-9690]
dc.contributor.orcidEijssen, Lars [0000-0002-6473-2839]
dc.contributor.orcidEhrhart, Friederike [0000-0002-7770-620X]
dc.contributor.orcidRex, Devasahayam Arokia Balaya [0000-0002-9556-3150]
dc.contributor.orcidSlenter, Denise [0000-0001-8449-1318]
dc.contributor.orcidMartens, Marvin [0000-0003-2230-0840]
dc.contributor.orcidPham, Nhung [0000-0003-3091-3962]
dc.contributor.orcidHaw, Robin [0000-0002-2013-7835]
dc.contributor.orcidJassal, Bijay [0000-0002-5039-5405]
dc.contributor.orcidMatthews, Lisa [0000-0001-5707-3065]
dc.contributor.orcidOrlic-Milacic, Marija [0000-0002-3218-5631]
dc.contributor.orcidSenff Ribeiro, Andrea [0000-0002-7967-6307]
dc.contributor.orcidRothfels, Karen [0000-0002-0705-7048]
dc.contributor.orcidStephan, Ralf [0000-0002-4650-631X]
dc.contributor.orcidSevilla, Cristoffer [0000-0002-8570-4650]
dc.contributor.orcidVarusai, Thawfeek [0000-0002-7864-5971]
dc.contributor.orcidRavel, Jean-Marie [0000-0001-7038-7341]
dc.contributor.orcidFraser, Rupsha [0000-0002-3847-3554]
dc.contributor.orcidOrtseifen, Vera [0000-0001-5977-798X]
dc.contributor.orcidMarchesi, Silvia [0000-0003-4791-4507]
dc.contributor.orcidGawron, Piotr [0000-0002-9328-8052]
dc.contributor.orcidSmula, Ewa [0000-0001-7118-3164]
dc.contributor.orcidHeirendt, Laurent [0000-0003-1861-0037]
dc.contributor.orcidSatagopam, Venkata [0000-0002-6532-5880]
dc.contributor.orcidWu, Guanming [0000-0001-8196-1177]
dc.contributor.orcidRiutta, Anders [0000-0002-4693-0591]
dc.contributor.orcidGolebiewski, Martin [0000-0002-8683-7084]
dc.contributor.orcidOwen, Stuart [0000-0003-2130-0865]
dc.contributor.orcidGoble, Carole [0000-0003-1219-2137]
dc.contributor.orcidHu, Xiaoming [0000-0002-8318-3222]
dc.contributor.orcidOverall, Rupert W [0000-0002-3882-6073]
dc.contributor.orcidBauch, Angela [0000-0002-8712-4414]
dc.contributor.orcidGyori, Benjamin M [0000-0001-9439-5346]
dc.contributor.orcidBachman, John A [0000-0001-6095-2466]
dc.contributor.orcidVega, Carlos [0000-0002-7979-9921]
dc.contributor.orcidGrouès, Valentin [0000-0001-6501-0806]
dc.contributor.orcidVazquez, Miguel [0000-0002-5713-1058]
dc.contributor.orcidPorras, Pablo [0000-0002-8429-8793]
dc.contributor.orcidLicata, Luana [0000-0001-5084-9000]
dc.contributor.orcidSacco, Francesca [0000-0001-5586-9529]
dc.contributor.orcidNesterova, Anastasia [0000-0002-9448-8101]
dc.contributor.orcidde Waard, Anita [0000-0002-9034-4119]
dc.contributor.orcidTurei, Denes [0000-0002-7249-9379]
dc.contributor.orcidLuna, Augustin [0000-0001-5709-371X]
dc.contributor.orcidBabur, Ozgun [0000-0002-0239-5259]
dc.contributor.orcidSoliman, Sylvain [0000-0001-5525-7418]
dc.contributor.orcidValdeolivas, Alberto [0000-0001-5482-9023]
dc.contributor.orcidEsteban-Medina, Marina [0000-0003-2632-9587]
dc.contributor.orcidPeña-Chilet, Maria [0000-0002-6445-9617]
dc.contributor.orcidRian, Kinza [0000-0003-4314-7208]
dc.contributor.orcidHelikar, Tomáš [0000-0003-3653-1906]
dc.contributor.orcidPuniya, Bhanwar Lal [0000-0001-7528-3568]
dc.contributor.orcidModos, Dezso [0000-0001-9412-6867]
dc.contributor.orcidTreveil, Agatha [0000-0002-5600-8189]
dc.contributor.orcidOlbei, Marton [0000-0002-4903-6237]
dc.contributor.orcidDe Meulder, Bertrand [0000-0002-2108-7657]
dc.contributor.orcidBallereau, Stephane [0000-0002-8479-3110]
dc.contributor.orcidDugourd, Aurélien [0000-0002-0714-028X]
dc.contributor.orcidNaldi, Aurélien [0000-0002-6495-2655]
dc.contributor.orcidNoël, Vincent [0000-0003-3448-291X]
dc.contributor.orcidCalzone, Laurence [0000-0002-7835-1148]
dc.contributor.orcidSander, Chris [0000-0001-6059-6270]
dc.contributor.orcidDemir, Emek [0000-0002-3663-7113]
dc.contributor.orcidKorcsmaros, Tamas [0000-0003-1717-996X]
dc.contributor.orcidFreeman, Tom C [0000-0001-5235-8483]
dc.contributor.orcidAugé, Franck [0000-0002-5641-4152]
dc.contributor.orcidBeckmann, Jacques S [0000-0002-9741-1900]
dc.contributor.orcidHasenauer, Jan [0000-0002-4935-3312]
dc.contributor.orcidWolkenhauer, Olaf [0000-0001-6105-2937]
dc.contributor.orcidWilighagen, Egon L [0000-0001-7542-0286]
dc.contributor.orcidPico, Alexander R [0000-0001-5706-2163]
dc.contributor.orcidEvelo, Chris T [0000-0002-5301-3142]
dc.contributor.orcidGillespie, Marc E [0000-0002-5766-1702]
dc.contributor.orcidStein, Lincoln D [0000-0002-1983-4588]
dc.contributor.orcidHermjakob, Henning [0000-0001-8479-0262]
dc.contributor.orcidD'Eustachio, Peter [0000-0002-5494-626X]
dc.contributor.orcidSaez-Rodriguez, Julio [0000-0002-8552-8976]
dc.contributor.orcidDopazo, Joaquin [0000-0003-3318-120X]
dc.contributor.orcidValencia, Alfonso [0000-0002-8937-6789]
dc.contributor.orcidKitano, Hiroaki [0000-0002-3589-1953]
dc.contributor.orcidBarillot, Emmanuel [0000-0003-2724-2002]
dc.contributor.orcidAuffray, Charles [0000-0003-2226-7411]
dc.contributor.orcidBalling, Rudi [0000-0003-2902-5650]
dc.contributor.orcidSchneider, Reinhard [0000-0002-8278-1618]
pubs.funder-project-idFonds National de la Recherche Luxembourg (COVID‐19/2020‐1/14715687/CovScreen)
pubs.funder-project-idFonds National de la Recherche Luxembourg (FNR) (COVID-19/2020-1/14715687/CovScreen)
pubs.funder-project-idH2020 Marie Skłodowska-Curie Actions (765274)
pubs.funder-project-idNHGRI NIH HHS (U41 HG003751)
pubs.funder-project-idZonMw (10430012010015)
pubs.funder-project-idH2020 LEIT Information and Communication Technologies (H2020‐ICT‐951773, H2020‐ICT‐825070)
pubs.funder-project-idEC | H2020 | H2020 Priority Industrial Leadership | LEIT | H2020 LEIT Information and Communication Technologies (ICT) (H2020-ICT-951773, H2020-ICT-825070)
pubs.funder-project-idAssociation Nationale de la Recherche et de la Technologie (2020/0766)
pubs.funder-project-idAssociation Nationale de la Recherche et de la Technologie (ANRT) (2020/0766)
pubs.funder-project-idDeutsches Zentrum für Infektionsforschung (8020708703)
pubs.funder-project-idDeutsches Zentrum für Infektionsforschung (DZIF) (8020708703)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International