Show simple item record

dc.contributor.authorNounu, Aayah
dc.contributor.authorRichmond, Rebecca C
dc.contributor.authorStewart, Isobel
dc.contributor.authorSurendran, Praveen
dc.contributor.authorWareham, Nicholas
dc.contributor.authorButterworth, Adam
dc.contributor.authorWeinstein, Stephanie J
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorBaron, John A
dc.contributor.authorHopper, John L
dc.contributor.authorFigueiredo, Jane C
dc.contributor.authorNewcomb, Polly A
dc.contributor.authorLindor, Noralane M
dc.contributor.authorCasey, Graham
dc.contributor.authorPlatz, Elizabeth A
dc.contributor.authorMarchand, Loïc Le
dc.contributor.authorUlrich, Cornelia M
dc.contributor.authorLi, Christopher I
dc.contributor.authorvan Dujinhoven, Fränzel JB
dc.contributor.authorGsur, Andrea
dc.contributor.authorCampbell, Peter T
dc.contributor.authorMoreno, Víctor
dc.contributor.authorVodicka, Pavel
dc.contributor.authorVodickova, Ludmila
dc.contributor.authorAmitay, Efrat
dc.contributor.authorAlwers, Elizabeth
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorSakoda, Lori C
dc.contributor.authorSlattery, Martha L
dc.contributor.authorSchoen, Robert E
dc.contributor.authorGunter, Marc J
dc.contributor.authorCastellví-Bel, Sergi
dc.contributor.authorKim, Hyeong-Rok
dc.contributor.authorKweon, Sun-Seog
dc.contributor.authorChan, Andrew T
dc.contributor.authorLi, Li
dc.contributor.authorZheng, Wei
dc.contributor.authorBishop, D Timothy
dc.contributor.authorBuchanan, Daniel D
dc.contributor.authorGiles, Graham G
dc.contributor.authorGruber, Stephen B
dc.contributor.authorRennert, Gad
dc.contributor.authorStadler, Zsofia K
dc.contributor.authorHarrison, Tabitha A
dc.contributor.authorLin, Yi
dc.contributor.authorKeku, Temitope O
dc.contributor.authorWoods, Michael O
dc.contributor.authorSchafmayer, Clemens
dc.contributor.authorVan Guelpen, Bethany
dc.contributor.authorGallinger, Steven
dc.contributor.authorHampel, Heather
dc.contributor.authorBerndt, Sonja I
dc.contributor.authorPharoah, Paul
dc.contributor.authorLindblom, Annika
dc.contributor.authorWolk, Alicja
dc.contributor.authorWu, Anna H
dc.contributor.authorWhite, Emily
dc.contributor.authorPeters, Ulrike
dc.contributor.authorDrew, David A
dc.contributor.authorScherer, Dominique
dc.contributor.authorBermejo, Justo Lorenzo
dc.contributor.authorBrenner, Hermann
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorWilliams, Ann C
dc.contributor.authorRelton, Caroline L
dc.date.accessioned2021-11-23T00:29:03Z
dc.date.available2021-11-23T00:29:03Z
dc.date.issued2021-11-21
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330937
dc.description.abstractSalicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary statistics of SA (INTERVAL and EPIC-Norfolk, N = 14,149) and CRC (CCFR, CORECT, GECCO and UK Biobank, 55,168 cases and 65,160 controls). The DACHS study (4410 cases and 3441 controls) was used for replication and stratification of aspirin-use. SNPs proxying SA were selected via three methods: (1) functional SNPs that influence the activity of aspirin-metabolising enzymes; (2) pathway SNPs present in enzymes' coding regions; and (3) genome-wide significant SNPs. We found no association between functional SNPs and SA levels. The pathway and genome-wide SNPs showed no association between SA and CRC risk (OR: 1.03, 95% CI: 0.84-1.27 and OR: 1.08, 95% CI: 0.86-1.34, respectively). Results remained unchanged upon aspirin use stratification. We found little evidence to suggest that an SD increase in genetically predicted SA protects against CRC risk in the general population and upon stratification by aspirin use.
dc.languageen
dc.publisherMDPI AG
dc.subjectsalicylic acid
dc.subjectaspirin
dc.subjectcolorectal cancer
dc.subjectMendelian randomization
dc.titleSalicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.
dc.typeArticle
dc.date.updated2021-11-23T00:29:02Z
prism.issueIdentifier11
prism.publicationNameNutrients
prism.volume13
dc.identifier.doi10.17863/CAM.78381
dcterms.dateAccepted2021-11-17
rioxxterms.versionofrecord10.3390/nu13114164
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.contributor.orcidWeinstein, Stephanie J [0000-0002-3834-1535]
dc.contributor.orcidFigueiredo, Jane C [0000-0001-8040-3341]
dc.contributor.orcidMarchand, Loïc Le [0000-0001-5013-980X]
dc.contributor.orcidUlrich, Cornelia M [0000-0001-7641-059X]
dc.contributor.orcidGsur, Andrea [0000-0002-9795-1528]
dc.contributor.orcidMoreno, Víctor [0000-0002-2818-5487]
dc.contributor.orcidSakoda, Lori C [0000-0002-0900-5735]
dc.contributor.orcidCastellví-Bel, Sergi [0000-0003-1217-5097]
dc.contributor.orcidBuchanan, Daniel D [0000-0003-2225-6675]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidBermejo, Justo Lorenzo [0000-0002-6568-5333]
dc.contributor.orcidHoffmeister, Michael [0000-0002-8307-3197]
dc.identifier.eissn2072-6643
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (CH/12/2/29428)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
cam.issuedOnline2021-11-21


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record