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dc.contributor.authorCachia, Arnaud
dc.contributor.authorBorst, Grégoire
dc.contributor.authorJardri, Renaud
dc.contributor.authorRaznahan, Armin
dc.contributor.authorMurray, Graham
dc.contributor.authorMangin, Jean-François
dc.contributor.authorPlaze, Marion
dc.date.accessioned2021-11-23T00:30:32Z
dc.date.available2021-11-23T00:30:32Z
dc.date.issued2021
dc.identifier.issn1662-5129
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330949
dc.description.abstractGrowing evidence supports that prenatal processes play an important role for cognitive ability in normal and clinical conditions. In this context, several neuroimaging studies searched for features in postnatal life that could serve as a proxy for earlier developmental events. A very interesting candidate is the sulcal, or sulco-gyral, patterns, macroscopic features of the cortex anatomy related to the fold topology-e.g., continuous vs. interrupted/broken fold, present vs. absent fold-or their spatial organization. Indeed, as opposed to quantitative features of the cortical sheet (e.g., thickness, surface area or curvature) taking decades to reach the levels measured in adult, the qualitative sulcal patterns are mainly determined before birth and stable across the lifespan. The sulcal patterns therefore offer a window on the fetal constraints on specific brain areas on cognitive abilities and clinical symptoms that manifest later in life. After a global review of the cerebral cortex sulcation, its mechanisms, its ontogenesis along with methodological issues on how to measure the sulcal patterns, we present a selection of studies illustrating that analysis of the sulcal patterns can provide information on prenatal dispositions to cognition (with a focus on cognitive control and academic abilities) and cognitive symptoms (with a focus on schizophrenia and bipolar disorders). Finally, perspectives of sulcal studies are discussed.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleTowards Deciphering the Fetal Foundation of Normal Cognition and Cognitive Symptoms From Sulcation of the Cortex.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameFront Neuroanat
prism.startingPage712862
prism.volume15
dc.identifier.doi10.17863/CAM.78393
dcterms.dateAccepted2021-08-31
rioxxterms.versionofrecord10.3389/fnana.2021.712862
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-01
dc.contributor.orcidMurray, Graham [0000-0001-8296-1742]
dc.identifier.eissn1662-5129
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-09-28


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International