Show simple item record

dc.contributor.authorLi, Shuai
dc.contributor.authorSilvestri, Valentina
dc.contributor.authorLeslie, Goska
dc.contributor.authorRebbeck, Timothy R
dc.contributor.authorNeuhausen, Susan L
dc.contributor.authorHopper, John L
dc.contributor.authorNielsen, Henriette Roed
dc.contributor.authorLee, Andrew
dc.contributor.authorYang, Xin
dc.contributor.authorMcGuffog, Lesley
dc.contributor.authorParsons, Michael T
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorArnold, Norbert
dc.contributor.authorBelotti, Muriel
dc.contributor.authorBorg, Åke
dc.contributor.authorBuecher, Bruno
dc.contributor.authorBuys, Saundra S
dc.contributor.authorCaputo, Sandrine M
dc.contributor.authorChung, Wendy K
dc.contributor.authorColas, Chrystelle
dc.contributor.authorColonna, Sarah V
dc.contributor.authorCook, Jackie
dc.contributor.authorDaly, Mary B
dc.contributor.authorde la Hoya, Miguel
dc.contributor.authorde Pauw, Antoine
dc.contributor.authorDelhomelle, Hélène
dc.contributor.authorEason, Jacqueline
dc.contributor.authorEngel, Christoph
dc.contributor.authorEvans, D Gareth
dc.contributor.authorFaust, Ulrike
dc.contributor.authorFehm, Tanja N
dc.contributor.authorFostira, Florentia
dc.contributor.authorFountzilas, George
dc.contributor.authorFrone, Megan
dc.contributor.authorGarcia-Barberan, Vanesa
dc.contributor.authorGarre, Pilar
dc.contributor.authorGauthier-Villars, Marion
dc.contributor.authorGehrig, Andrea
dc.contributor.authorGlendon, Gord
dc.contributor.authorGoldgar, David E
dc.contributor.authorGolmard, Lisa
dc.contributor.authorGreene, Mark H
dc.contributor.authorHahnen, Eric
dc.contributor.authorHamann, Ute
dc.contributor.authorHanson, Helen
dc.contributor.authorHassan, Tiara
dc.contributor.authorHentschel, Julia
dc.contributor.authorHorvath, Judit
dc.contributor.authorIzatt, Louise
dc.contributor.authorJanavicius, Ramunas
dc.contributor.authorJiao, Yue
dc.contributor.authorJohn, Esther M
dc.contributor.authorKarlan, Beth Y
dc.contributor.authorKim, Sung-Won
dc.contributor.authorKonstantopoulou, Irene
dc.contributor.authorKwong, Ava
dc.contributor.authorLaugé, Anthony
dc.contributor.authorLee, Jong Won
dc.contributor.authorLesueur, Fabienne
dc.contributor.authorMebirouk, Noura
dc.contributor.authorMeindl, Alfons
dc.contributor.authorMouret-Fourme, Emmanuelle
dc.contributor.authorMusgrave, Hannah
dc.contributor.authorNgeow Yuen Yie, Joanne
dc.contributor.authorNiederacher, Dieter
dc.contributor.authorPark, Sue K
dc.contributor.authorPedersen, Inge Sokilde
dc.contributor.authorRamser, Juliane
dc.contributor.authorRamus, Susan J
dc.contributor.authorRantala, Johanna
dc.contributor.authorRashid, Muhammad U
dc.contributor.authorReichl, Florian
dc.contributor.authorRitter, Julia
dc.contributor.authorRump, Andreas
dc.contributor.authorSantamariña, Marta
dc.contributor.authorSaule, Claire
dc.contributor.authorSchmidt, Gunnar
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorSenter, Leigha
dc.contributor.authorShariff, Saba
dc.contributor.authorSinger, Christian F
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorStoppa-Lyonnet, Dominique
dc.contributor.authorSutter, Christian
dc.contributor.authorTan, Yen
dc.contributor.authorTeo, Soo Hwang
dc.contributor.authorTerry, Mary Beth
dc.contributor.authorThomassen, Mads
dc.contributor.authorTischkowitz, Marc
dc.contributor.authorToland, Amanda E
dc.contributor.authorTorres, Diana
dc.contributor.authorVega, Ana
dc.contributor.authorWagner, Sebastian A
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorWappenschmidt, Barbara
dc.contributor.authorWeber, Bernhard HF
dc.contributor.authorYannoukakos, Drakoulis
dc.contributor.authorSpurdle, Amanda B
dc.contributor.authorEaston, Douglas
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorOttini, Laura
dc.contributor.authorAntoniou, Antonis
dc.date.accessioned2021-11-24T00:30:33Z
dc.date.available2021-11-24T00:30:33Z
dc.date.issued2022-05-10
dc.identifier.issn0732-183X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331009
dc.description.abstractPURPOSE: To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management. METHODS: We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment. RESULTS: BRCA1 PVs were associated with risks of male breast (RR = 4.30; 95% CI, 1.09 to 16.96), pancreatic (RR = 2.36; 95% CI, 1.51 to 3.68), and stomach (RR = 2.17; 95% CI, 1.25 to 3.77) cancers. Associations with colorectal and gallbladder cancers were also suggested. BRCA2 PVs were associated with risks of male breast (RR = 44.0; 95% CI, 21.3 to 90.9), stomach (RR = 3.69; 95% CI, 2.40 to 5.67), pancreatic (RR = 3.34; 95% CI, 2.21 to 5.06), and prostate (RR = 2.22; 95% CI, 1.63 to 3.03) cancers. The stomach cancer RR was higher for females than males (6.89 v 2.76; P = .04). The absolute risks to age 80 years ranged from 0.4% for male breast cancer to approximately 2.5% for pancreatic cancer for BRCA1 carriers and from approximately 2.5% for pancreatic cancer to 27% for prostate cancer for BRCA2 carriers. CONCLUSION: In addition to female breast and ovarian cancers, BRCA1 and BRCA2 PVs are associated with increased risks of male breast, pancreatic, stomach, and prostate (only BRCA2 PVs) cancers, but not with the risks of other previously suggested cancers. The estimated age-specific risks will refine cancer risk management in men and women with BRCA1/2 PVs.
dc.description.sponsorshipCancer Research UK (C12292/A20861, 197 C12292/A11174 and PPRPGM-Nov20\100002)
dc.publisherAmerican Society of Clinical Oncology (ASCO)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants.
dc.typeArticle
prism.publicationNameJ Clin Oncol
dc.identifier.doi10.17863/CAM.78454
dcterms.dateAccepted2021-11-19
rioxxterms.versionofrecord10.1200/JCO.21.02112
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-19
dc.contributor.orcidLi, Shuai [0000-0002-8696-8594]
dc.contributor.orcidSilvestri, Valentina [0000-0003-0712-9379]
dc.contributor.orcidLeslie, Goska [0000-0001-5756-6222]
dc.contributor.orcidRebbeck, Timothy R [0000-0002-4799-1900]
dc.contributor.orcidNeuhausen, Susan L [0000-0001-5053-0390]
dc.contributor.orcidHopper, John L [0000-0002-8567-173X]
dc.contributor.orcidLee, Andrew [0000-0003-0677-0252]
dc.contributor.orcidYang, Xin [0000-0003-0037-3790]
dc.contributor.orcidParsons, Michael T [0000-0003-3242-8477]
dc.contributor.orcidAndrulis, Irene L [0000-0002-4226-6435]
dc.contributor.orcidBorg, Åke [0000-0002-5793-132X]
dc.contributor.orcidBuys, Saundra S [0000-0003-4120-5697]
dc.contributor.orcidCaputo, Sandrine M [0000-0001-5338-9388]
dc.contributor.orcidChung, Wendy K [0000-0003-3438-5685]
dc.contributor.orcidde la Hoya, Miguel [0000-0002-8113-1410]
dc.contributor.orcidde Pauw, Antoine [0000-0003-3898-073X]
dc.contributor.orcidEngel, Christoph [0000-0002-7247-282X]
dc.contributor.orcidFostira, Florentia [0000-0003-2751-2332]
dc.contributor.orcidFountzilas, George [0000-0001-8045-2186]
dc.contributor.orcidFrone, Megan [0000-0001-8273-8866]
dc.contributor.orcidGarre, Pilar [0000-0001-8285-4138]
dc.contributor.orcidGlendon, Gord [0000-0001-8630-6673]
dc.contributor.orcidGoldgar, David E [0000-0003-0697-9347]
dc.contributor.orcidGolmard, Lisa [0000-0002-5158-8284]
dc.contributor.orcidHahnen, Eric [0000-0002-1152-8367]
dc.contributor.orcidHanson, Helen [0000-0002-3303-8713]
dc.contributor.orcidHassan, Tiara [0000-0001-8282-0034]
dc.contributor.orcidJiao, Yue [0000-0001-9872-6034]
dc.contributor.orcidJohn, Esther M [0000-0003-3259-8003]
dc.contributor.orcidKarlan, Beth Y [0000-0002-9451-2933]
dc.contributor.orcidKonstantopoulou, Irene [0000-0002-0470-0309]
dc.contributor.orcidLee, Jong Won [0000-0001-7875-1603]
dc.contributor.orcidLesueur, Fabienne [0000-0001-7404-4549]
dc.contributor.orcidNgeow Yuen Yie, Joanne [0000-0003-1558-3627]
dc.contributor.orcidNiederacher, Dieter [0000-0001-6231-9226]
dc.contributor.orcidPedersen, Inge Sokilde [0000-0002-9902-8040]
dc.contributor.orcidRamus, Susan J [0000-0003-0005-7798]
dc.contributor.orcidRashid, Muhammad U [0000-0002-7684-3122]
dc.contributor.orcidRump, Andreas [0000-0001-7116-6364]
dc.contributor.orcidSaule, Claire [0000-0002-9639-8986]
dc.contributor.orcidSenter, Leigha [0000-0001-9270-8847]
dc.contributor.orcidShariff, Saba [0000-0002-9564-4890]
dc.contributor.orcidSinger, Christian F [0000-0003-1294-0027]
dc.contributor.orcidSouthey, Melissa C [0000-0002-6313-9005]
dc.contributor.orcidStoppa-Lyonnet, Dominique [0000-0002-5438-8309]
dc.contributor.orcidTeo, Soo Hwang [0000-0002-0444-590X]
dc.contributor.orcidTerry, Mary Beth [0000-0002-4106-5033]
dc.contributor.orcidTischkowitz, Marc [0000-0002-7880-0628]
dc.contributor.orcidToland, Amanda E [0000-0002-0271-1792]
dc.contributor.orcidVega, Ana [0000-0002-7416-5137]
dc.contributor.orcidWagner, Sebastian A [0000-0002-8629-6310]
dc.contributor.orcidWeber, Bernhard HF [0000-0002-8808-7723]
dc.contributor.orcidYannoukakos, Drakoulis [0000-0001-7509-3510]
dc.contributor.orcidSpurdle, Amanda B [0000-0003-1337-7897]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidChenevix-Trench, Georgia [0000-0002-1878-2587]
dc.contributor.orcidOttini, Laura [0000-0001-8030-0449]
dc.contributor.orcidAntoniou, Antonis [0000-0001-9223-3116]
dc.identifier.eissn1527-7755
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research UK (20861)
pubs.funder-project-idCancer Research UK (C12292/A31369)
cam.issuedOnline2022-01-25
cam.orpheus.success2022-03-07: VoR added to Apollo record


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International