Show simple item record

dc.contributor.authorWong, Hannah
dc.contributor.authorByrne, Stephanie
dc.contributor.authorRasotto, Roberta
dc.contributor.authorDrees, Randi
dc.contributor.authorTaylor, Angela
dc.contributor.authorPriestnall, Simon
dc.contributor.authorLeo, Chiara
dc.date.accessioned2021-11-24T00:30:42Z
dc.date.available2021-11-24T00:30:42Z
dc.identifier.issn2076-2615
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331013
dc.description.abstractCanine apocrine gland anal sac adenocarcinoma (AGASAC) is a malignant tumour with variable clinical progression. The objective of this study was to use robust multivariate models, based on models employed in human medical oncology, to establish clinical and histopathological risk factors of poor survival. Clinical data and imaging of 81 cases with AGASAC were reviewed. Tissue was available for histological review and immunohistochemistry in 49 cases. Tumour and lymph node size were determined using the response evaluation criteria in the solid tumours sys-tem (RECIST). Modelling revealed tumour size over 2 cm, lymph node size grouped in three tiers by the two thresholds 1.6 cm and 5 cm, surgical management, and radiotherapy were independ-ent clinical variables associated with survival, irrespective of tumour stage. Tumour size over 1.3 cm and presence of distant metastasis were independent clinical variables associated with the first progression-free interval. The presence of the histopathological variables of tumour necrosis, a solid histological pattern, and vascular invasion in the primary tumour were independent risk factors of poor survival. Based upon these independent risk factors, scoring algorithms to predict survival in AGASAC patients are presented.
dc.description.sponsorshipThe research allowance provided by the Royal Veterinary College as part of the Senior Clinical Training Scholar Residency Program.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome
dc.typeArticle
prism.publicationNameAnimals
dc.identifier.doi10.17863/CAM.78458
dcterms.dateAccepted2021-11-19
rioxxterms.versionofrecord10.3390/ani11113327.
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-19
dc.contributor.orcidWong, Hannah [0000-0002-9530-7106]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (096413/Z/11/Z)
cam.issuedOnline2021-11-22
datacite.issupplementedby.doi10.5061/dryad.x95x69pgx.
cam.orpheus.success2021-11-23 - Embargo set during processing via Fast-track
rioxxterms.freetoread.startdate2021-11-22


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International