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dc.contributor.authorWinzeler, Bettina
dc.contributor.authorChallis, Benjamin G
dc.contributor.authorCasey, Ruth T
dc.date.accessioned2021-11-25T00:24:16Z
dc.date.available2021-11-25T00:24:16Z
dc.date.issued2021-11-22
dc.identifier.issn2075-4426
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331049
dc.description.abstractPrecision medicine is a term used to describe medical care, which is specifically tailored to an individual patient or disease with the aim of ensuring the best clinical outcome whilst reducing the risk of adverse effects. Phaeochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumours with uncertain malignant potential. Over recent years, the molecular profiling of PPGLs has increased our understanding of the mechanisms that drive tumorigenesis. A high proportion of PPGLs are hereditary, with non-hereditary tumours commonly harbouring somatic mutations in known susceptibility genes. Through detailed interrogation of genotype-phenotype, correlations PPGLs can be classified into three different subgroups or clusters. Thus, PPGLs serve as an ideal paradigm for developing, testing and implementing precision medicine concepts in the clinic. In this review, we provide an overview of PPGLs and highlight how detailed molecular characterisation of these tumours provides current and future opportunities for precision oncology.
dc.languageen
dc.publisherMDPI AG
dc.subjectpersonalized medicine
dc.subjectneuroendocrine tumours
dc.subjectphaeochromocytoma
dc.subjectparaganglioma
dc.subjectmolecular clusters
dc.titlePrecision Medicine in Phaeochromocytoma and Paraganglioma.
dc.typeArticle
dc.date.updated2021-11-25T00:24:16Z
prism.issueIdentifier11
prism.publicationNameJ Pers Med
prism.volume11
dc.identifier.doi10.17863/CAM.78494
dcterms.dateAccepted2021-11-17
rioxxterms.versionofrecord10.3390/jpm11111239
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWinzeler, Bettina [0000-0001-8305-2700]
dc.identifier.eissn2075-4426
pubs.funder-project-idGIST SUPPORT UK (n/a)
cam.issuedOnline2021-11-22


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