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dc.contributor.authorMurray, Gemma
dc.contributor.authorBalmer, Andrew
dc.contributor.authorHerbert, Josephine
dc.contributor.authorHadijirin, Nazreen F
dc.contributor.authorKemp, Caroline L
dc.contributor.authorMatuszewska, Marta
dc.contributor.authorBruchmann, Sebastian
dc.contributor.authorHossain, AS Md Mukarram
dc.contributor.authorGottschalk, Marcelo
dc.contributor.authorTucker, Alexander
dc.contributor.authorMiller, Eric
dc.contributor.authorWeinert, Lucy
dc.date.accessioned2021-11-25T00:31:03Z
dc.date.available2021-11-25T00:31:03Z
dc.date.issued2021-11
dc.identifier.issn1553-7390
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331069
dc.description.abstractMutation rates vary both within and between bacterial species, and understanding what drives this variation is essential for understanding the evolutionary dynamics of bacterial populations. In this study, we investigate two factors that are predicted to influence the mutation rate: ecology and genome size. We conducted mutation accumulation experiments on eight strains of the emerging zoonotic pathogen Streptococcus suis. Natural variation within this species allows us to compare tonsil carriage and invasive disease isolates, from both more and less pathogenic populations, with a wide range of genome sizes. We find that invasive disease isolates have repeatedly evolved mutation rates that are higher than those of closely related carriage isolates, regardless of variation in genome size. Independent of this variation in overall rate, we also observe a stronger bias towards G/C to A/T mutations in isolates from more pathogenic populations, whose genomes tend to be smaller and more AT-rich. Our results suggest that ecology is a stronger correlate of mutation rate than genome size over these timescales, and that transitions to invasive disease are consistently accompanied by rapid increases in mutation rate. These results shed light on the impact that ecology can have on the adaptive potential of bacterial pathogens.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.
dc.typeArticle
prism.endingPagee1009864
prism.issueIdentifier11
prism.publicationNamePLoS Genetics
prism.startingPagee1009864
prism.volume17
dc.identifier.doi10.17863/CAM.78514
dcterms.dateAccepted2021-10-06
rioxxterms.versionofrecord10.1371/journal.pgen.1009864
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-10-06
dc.contributor.orcidMurray, Gemma [0000-0002-9531-1711]
dc.contributor.orcidBalmer, Andrew [0000-0001-7446-3428]
dc.contributor.orcidMatuszewska, Marta [0000-0002-2653-7725]
dc.contributor.orcidBruchmann, Sebastian [0000-0001-8721-5386]
dc.contributor.orcidTucker, Alexander [0000-0003-0062-0843]
dc.contributor.orcidWeinert, Lucy [0000-0002-9279-6012]
dc.identifier.eissn1553-7404
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L018934/1)
pubs.funder-project-idWellcome Trust (109385/Z/15/Z)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (727966)
pubs.funder-project-idBBSRC (2113638)
cam.issuedOnline2021-11-08


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International