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dc.contributor.authorHarding, Simonen
dc.contributor.authorArmstrong, Janeen
dc.contributor.authorFaccenda, Elenaen
dc.contributor.authorSouthan, Christopheren
dc.contributor.authorAlexander, Stephenen
dc.contributor.authorDavenport, Anthonyen
dc.contributor.authorPawson, Adamen
dc.contributor.authorSpedding, Michaelen
dc.contributor.authorDavies, Jamieen
dc.description.abstractThe IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY ( Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.
dc.description.sponsorshipI am a contributing author. Open Access CC-BY is funded by the University of Edinburgh Wellcome Trust Institutional Strategic Support Fund. The manuscript has a statement: For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
dc.publisherOxford University Press
dc.rightsAttribution 4.0 International
dc.titleThe IUPHAR/BPS Guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterialsen
prism.publicationNameNucleic Acids Researchen
dc.contributor.orcidDavenport, Anthony [0000-0002-2096-3117]
rioxxterms.typeJournal Article/Reviewen

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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International