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dc.contributor.authorLuan, Haiwen
dc.contributor.authorZhang, Qihui
dc.contributor.authorLiu, Tzu-Li
dc.contributor.authorWang, Xueju
dc.contributor.authorZhao, Shiwei
dc.contributor.authorWang, Heling
dc.contributor.authorYao, Shenglian
dc.contributor.authorXue, Yeguang
dc.contributor.authorKwak, Jean Won
dc.contributor.authorBai, Wubin
dc.contributor.authorXu, Yameng
dc.contributor.authorHan, Mengdi
dc.contributor.authorLi, Kan
dc.contributor.authorLi, Zhengwei
dc.contributor.authorNi, Xinchen
dc.contributor.authorYe, Jilong
dc.contributor.authorChoi, Dongwhi
dc.contributor.authorYang, Quansan
dc.contributor.authorKim, Jae-Hwan
dc.contributor.authorLi, Shuo
dc.contributor.authorChen, Shulin
dc.contributor.authorWu, Changsheng
dc.contributor.authorLu, Di
dc.contributor.authorChang, Jan-Kai
dc.contributor.authorXie, Zhaoqian
dc.contributor.authorHuang, Yonggang
dc.contributor.authorRogers, John A
dc.date.accessioned2021-11-25T02:02:29Z
dc.date.available2021-11-25T02:02:29Z
dc.date.issued2021-10-22
dc.identifier.issn2375-2548
dc.identifier.otherPMC8528415
dc.identifier.other34669471
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331087
dc.description.abstractMicrofluidic technologies have wide-ranging applications in chemical analysis systems, drug delivery platforms, and artificial vascular networks. This latter area is particularly relevant to 3D cell cultures, engineered tissues, and artificial organs, where volumetric capabilities in fluid distribution are essential. Existing schemes for fabricating 3D microfluidic structures are constrained in realizing desired layout designs, producing physiologically relevant microvascular structures, and/or integrating active electronic/optoelectronic/microelectromechanical components for sensing and actuation. This paper presents a guided assembly approach that bypasses these limitations to yield complex 3D microvascular structures from 2D precursors that exploit the full sophistication of 2D fabrication methods. The capabilities extend to feature sizes <5 μm, in extended arrays and with various embedded sensors and actuators, across wide ranges of overall dimensions, in a parallel, high-throughput process. Examples include 3D microvascular networks with sophisticated layouts, deterministically designed and constructed to expand the geometries and operating features of artificial vascular networks.
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceessn: 2375-2548
dc.sourcenlmid: 101653440
dc.titleComplex 3D microfluidic architectures formed by mechanically guided compressive buckling.
dc.typeArticle
dc.date.updated2021-11-25T02:02:28Z
prism.issueIdentifier43
prism.publicationNameSci Adv
prism.volume7
dc.identifier.doi10.17863/CAM.78532
dc.identifier.doi10.17863/CAM.78532
rioxxterms.versionofrecord10.1126/sciadv.abj3686
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.contributor.orcidLuan, Haiwen [0000-0003-0722-1108]
dc.contributor.orcidWang, Xueju [0000-0002-0669-8759]
dc.contributor.orcidZhao, Shiwei [0000-0002-9797-1334]
dc.contributor.orcidWang, Heling [0000-0001-7859-5153]
dc.contributor.orcidXue, Yeguang [0000-0002-1968-5092]
dc.contributor.orcidKwak, Jean Won [0000-0001-7883-9242]
dc.contributor.orcidBai, Wubin [0000-0003-2872-5559]
dc.contributor.orcidLi, Kan [0000-0003-4864-3446]
dc.contributor.orcidNi, Xinchen [0000-0002-3327-3764]
dc.contributor.orcidChoi, Dongwhi [0000-0002-9286-2710]
dc.contributor.orcidYang, Quansan [0000-0001-8029-1327]
dc.contributor.orcidKim, Jae-Hwan [0000-0002-8940-652X]
dc.contributor.orcidLi, Shuo [0000-0003-4913-730X]
dc.contributor.orcidChang, Jan-Kai [0000-0002-3056-1250]
dc.contributor.orcidXie, Zhaoqian [0000-0003-1320-817X]
dc.contributor.orcidHuang, Yonggang [0000-0002-0483-8359]
dc.contributor.orcidRogers, John A [0000-0002-3830-5980]
dc.identifier.eissn2375-2548


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International