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dc.contributor.authorPark, JY
dc.contributor.authorDahm, CC
dc.contributor.authorKeogh, Ruth
dc.contributor.authorMitrou, Panagiota
dc.contributor.authorCairns, BJ
dc.contributor.authorGreenwood, DC
dc.contributor.authorSpencer, EA
dc.contributor.authorFentiman, IS
dc.contributor.authorShipley, MJ
dc.contributor.authorBrunner, EJ
dc.contributor.authorCade, JE
dc.contributor.authorBurley, VJ
dc.contributor.authorMishra, GD
dc.contributor.authorKuh, D
dc.contributor.authorStephen, AM
dc.contributor.authorWhite, IR
dc.contributor.authorLuben, Robert
dc.contributor.authorMulligan, Angela
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorRodwell, SA
dc.date.accessioned2021-11-25T11:39:56Z
dc.date.available2021-11-25T11:39:56Z
dc.date.issued2010-08-24
dc.identifier.issn0007-0920
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331121
dc.description.abstractBACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent. METHODS: We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ). RESULTS: Compared with individuals in the lightest category of drinkers (>0-<5 g per day), the multivariable odds ratios of CRC were 1.16 (95% confidence interval (95% CI): 0.88, 1.53) for non-drinkers, 0.91 (95% CI: 0.67, 1.24) for drinkers with 5-<15 g per day, 0.90 (95% CI: 0.65, 1.25) for drinkers with 15-<30 g per day, 1.02 (95% CI: 0.66, 1.58) for drinkers with 30-<45 g per day and 1.19 (95% CI: 0.75, 1.91) for drinkers with >or=45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results. CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectDiet
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectAlcohol Drinking
dc.subjectSmoking
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectUnited Kingdom
dc.titleAlcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium.
dc.typeArticle
prism.endingPage756
prism.issueIdentifier5
prism.publicationDate2010
prism.publicationNameBr J Cancer
prism.startingPage747
prism.volume103
dc.identifier.doi10.17863/CAM.78568
dc.identifier.doi10.17863/CAM.78568
rioxxterms.versionofrecord10.1038/sj.bjc.6605802
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2010-08
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidMulligan, Angela [0000-0001-5546-971X]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.identifier.eissn1532-1827
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (G0500300)
pubs.funder-project-idMRC (UD99999933)
cam.issuedOnline2010-07-20


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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-ShareAlike 4.0 International