Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium.
dc.contributor.author | Park, JY | |
dc.contributor.author | Dahm, CC | |
dc.contributor.author | Keogh, Ruth | |
dc.contributor.author | Mitrou, Panagiota | |
dc.contributor.author | Cairns, BJ | |
dc.contributor.author | Greenwood, DC | |
dc.contributor.author | Spencer, EA | |
dc.contributor.author | Fentiman, IS | |
dc.contributor.author | Shipley, MJ | |
dc.contributor.author | Brunner, EJ | |
dc.contributor.author | Cade, JE | |
dc.contributor.author | Burley, VJ | |
dc.contributor.author | Mishra, GD | |
dc.contributor.author | Kuh, D | |
dc.contributor.author | Stephen, AM | |
dc.contributor.author | White, IR | |
dc.contributor.author | Luben, Robert | |
dc.contributor.author | Mulligan, Angela | |
dc.contributor.author | Khaw, Kay-Tee | |
dc.contributor.author | Rodwell, SA | |
dc.date.accessioned | 2021-11-25T11:39:56Z | |
dc.date.available | 2021-11-25T11:39:56Z | |
dc.date.issued | 2010-08-24 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/331121 | |
dc.description.abstract | BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent. METHODS: We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ). RESULTS: Compared with individuals in the lightest category of drinkers (>0-<5 g per day), the multivariable odds ratios of CRC were 1.16 (95% confidence interval (95% CI): 0.88, 1.53) for non-drinkers, 0.91 (95% CI: 0.67, 1.24) for drinkers with 5-<15 g per day, 0.90 (95% CI: 0.65, 1.25) for drinkers with 15-<30 g per day, 1.02 (95% CI: 0.66, 1.58) for drinkers with 30-<45 g per day and 1.19 (95% CI: 0.75, 1.91) for drinkers with >or=45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results. CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.subject | Humans | |
dc.subject | Colorectal Neoplasms | |
dc.subject | Diet | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Alcohol Drinking | |
dc.subject | Smoking | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | United Kingdom | |
dc.title | Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium. | |
dc.type | Article | |
prism.endingPage | 756 | |
prism.issueIdentifier | 5 | |
prism.publicationDate | 2010 | |
prism.publicationName | Br J Cancer | |
prism.startingPage | 747 | |
prism.volume | 103 | |
dc.identifier.doi | 10.17863/CAM.78568 | |
dc.identifier.doi | 10.17863/CAM.78568 | |
rioxxterms.versionofrecord | 10.1038/sj.bjc.6605802 | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2010-08 | |
dc.contributor.orcid | Luben, Robert [0000-0002-5088-6343] | |
dc.contributor.orcid | Mulligan, Angela [0000-0001-5546-971X] | |
dc.contributor.orcid | Khaw, Kay-Tee [0000-0002-8802-2903] | |
dc.identifier.eissn | 1532-1827 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | Medical Research Council (G0401527) | |
pubs.funder-project-id | Medical Research Council (G0500300) | |
pubs.funder-project-id | MRC (UD99999933) | |
cam.issuedOnline | 2010-07-20 |
Files in this item
This item appears in the following Collection(s)
-
Cambridge University Research Outputs
Research outputs of the University of Cambridge