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dc.contributor.authorHo, Frederick K
dc.contributor.authorMan, Kenneth KC
dc.contributor.authorToshner, Mark
dc.contributor.authorChurch, Colin
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorWong, Ian CK
dc.contributor.authorBerry, Colin
dc.contributor.authorSattar, Naveed
dc.contributor.authorPell, Jill P
dc.date.accessioned2021-11-25T11:49:55Z
dc.date.available2021-11-25T11:49:55Z
dc.date.issued2021-10
dc.identifier.issn0025-6196
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331139
dc.description.abstractOBJECTIVE: To assess the associations between coronavirus disease 2019 (COVID-19) infection and thromboembolism including myocardial infarction (MI), ischemic stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE). PATIENTS AND METHODS: A self-controlled case-series study was conducted covering the whole of Scotland's general population. The study population comprised individuals with confirmed (positive test) COVID-19 and at least one thromboembolic event between March 2018 and October 2020. Their incidence rates during the risk interval (5 days before to 56 days after the positive test) and the control interval (the remaining periods) were compared intrapersonally. RESULTS: Across Scotland, 1449 individuals tested positive for COVID-19 and experienced a thromboembolic event. The risk of thromboembolism was significantly elevated over the whole risk period but highest in the 7 days following the positive test (incidence rate ratio, 12.01; 95% CI, 9.91 to 14.56) in all included individuals. The association was also present in individuals not originally hospitalized for COVID-19 (incidence rate ratio, 4.07; 95% CI, 2.83 to 5.85). Risk of MI, stroke, PE, and DVT were all significantly higher in the week following a positive test. The risk of PE and DVT was particularly high and remained significantly elevated even 56 days following the test. CONCLUSION: Confirmed COVID-19 infection was associated with early elevations in risk with MI, ischemic stroke, and substantially stronger and prolonged elevations with DVT and PE both in hospital and community settings. Clinicians should consider thromboembolism, especially PE, among people with COVID-19 in the community.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectPulmonary Embolism
dc.subjectThromboembolism
dc.subjectHospitalization
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectScotland
dc.subjectMale
dc.subjectCOVID-19
dc.titleThromboembolic Risk in Hospitalized and Nonhospitalized COVID-19 Patients: A Self-Controlled Case Series Analysis of a Nationwide Cohort.
dc.typeArticle
prism.endingPage2597
prism.issueIdentifier10
prism.publicationDate2021
prism.publicationNameMayo Clin Proc
prism.startingPage2587
prism.volume96
dc.identifier.doi10.17863/CAM.78586
dc.identifier.doi10.17863/CAM.78586
dcterms.dateAccepted2021-07-02
rioxxterms.versionofrecord10.1016/j.mayocp.2021.07.002
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-10
dc.contributor.orcidToshner, Mark [0000-0002-3969-6143]
dc.identifier.eissn1942-5546
rioxxterms.typeJournal Article/Review


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International