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dc.contributor.authorLewis, Lucy N
dc.contributor.authorHayhoe, Richard PG
dc.contributor.authorMulligan, Angela
dc.contributor.authorLuben, Robert
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWelch, Ailsa A
dc.date.accessioned2021-11-25T17:29:00Z
dc.date.available2021-11-25T17:29:00Z
dc.date.issued2020-10-12
dc.identifier.issn0022-3166
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331183
dc.description.abstractBACKGROUND: Age-related loss of skeletal muscle mass contributes to poor outcomes including sarcopenia, physical disability, frailty, type 2 diabetes, and mortality. Vitamin C has physiological relevance to skeletal muscle and may protect it during aging, but few studies have investigated its importance in older populations. OBJECTIVES: We aimed to investigate cross-sectional associations of dietary and plasma vitamin C with proxy measures of skeletal muscle mass in a large cohort of middle- and older-aged individuals. METHODS: We analyzed data from >13,000 men and women in the European Prospective Investigation into Cancer and Nutrition-Norfolk cohort, aged 42-82 y. Fat-free mass (FFM), as a proxy for skeletal muscle mass, was estimated using bioelectrical impedance analysis and expressed as a percentage of total mass (FFM%) or standardized by BMI (FFMBMI). Dietary vitamin C intakes were calculated from 7-d food diary data, and plasma vitamin C was measured in peripheral blood. Multivariable regression models, including relevant lifestyle, dietary, and biological covariates, were used to determine associations between FFM measures and quintiles of dietary vitamin C or insufficient compared with sufficient plasma vitamin C (<50 μmol/L and ≥50 μmol/L). RESULTS: Positive trends were found across quintiles of dietary vitamin C and FFM measures for both sexes, with interquintile differences in FFM% and FFMBMI of 1.0% and 2.3% for men and 1.9% and 2.9% for women, respectively (all P < 0.001). Similarly, FFM% and FFMBMI measures were higher in participants with sufficient than with insufficient plasma vitamin C: by 1.6% and 2.0% in men, and 3.4% and 3.9% in women, respectively (all P < 0.001). Associations were also evident in analyses stratified into <65-y and ≥65-y age groups. CONCLUSIONS: Our findings of positive associations, of both dietary and circulating vitamin C with measures of skeletal muscle mass in middle- and older-aged men and women, suggest that dietary vitamin C intake may be useful for reducing age-related muscle loss.
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMuscle, Skeletal
dc.subjectHumans
dc.subjectAscorbic Acid
dc.subjectDiet
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleLower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass.
dc.typeArticle
prism.endingPage2798
prism.issueIdentifier10
prism.publicationDate2020
prism.publicationNameJ Nutr
prism.startingPage2789
prism.volume150
dc.identifier.doi10.17863/CAM.78630
dc.identifier.doi10.17863/CAM.78630
dcterms.dateAccepted2020-07-07
rioxxterms.versionofrecord10.1093/jn/nxaa221
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-10
dc.contributor.orcidMulligan, Angela [0000-0001-5546-971X]
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.identifier.eissn1541-6100
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idMedical Research Council (G0500300)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
cam.issuedOnline2020-08-27


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International