Show simple item record

dc.contributor.authorJennings, Amy
dc.contributor.authorMulligan, Angela
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorLuben, Robert
dc.contributor.authorWelch, Ailsa A
dc.date.accessioned2021-11-25T17:29:03Z
dc.date.available2021-11-25T17:29:03Z
dc.date.issued2020-04-21
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331184
dc.description.abstractResearch on Mediterranean diet (MD) adherence and musculoskeletal health is limited. The current study determined if adherence to the alternative MD score (aMED) and MD score (MDS), quantified from 7-d food diaries, was associated with fracture incidence, bone density (calcaneal broadband ultrasound attenuation (BUA)) and fat free mass (expressed over BMI (FFMBMI) using bioelectrical impedance) in 25,450 men and women recruited to the European Prospective Investigation into Cancer study in Norfolk, UK. During 17.4 years of follow up (443,178 total person years) 2195 incident fractures occurred. Higher aMED adherence was associated with 23% reduced total (Q5-Q1 HR 0.77; 95% CI 0.67, 0.88; p-trend < 0.01) and 21% reduced hip (Q5-Q1 HR 0.79; 95% CI 0.65, 0.96; p-trend = 0.01) fracture incidence, and significantly higher BUA (Q5-Q1 1.0 dB/MHz 95% CI 0.2, 1.9; p-trend < 0.01) and FFMBMI (Q5-Q1 0.05 kg/(kg/m2) 95% CI 0.04, 0.06; p-trend < 0.01), comparing extreme adherence quintiles. Higher MDS was also associated with reduced total fractures (Q5-Q1 HR 0.83; 95% CI 0.71, 0.96; p-trend = 0.03) and significantly higher BUA (Q5-Q1 1.4 dB/MHz 95% CI 0.5, 2.3; p-trend < 0.01) and FFMBMI (Q5-Q1 0.03 kg/(kg/m2) 95% CI 0.01, 0.04; p-trend < 0.01). This evidence supports the need to develop interventions to enhance MD adherence, particularly in women, where evidence for associations was stronger.
dc.format.mediumElectronic
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMuscles
dc.subjectBone and Bones
dc.subjectHumans
dc.subjectBody Mass Index
dc.subjectFollow-Up Studies
dc.subjectDiet, Mediterranean
dc.subjectBone Density
dc.subjectFemale
dc.subjectMale
dc.subjectBody Fat Distribution
dc.subjectFractures, Bone
dc.subjectNutritional Physiological Phenomena
dc.subjectUnited Kingdom
dc.subjectTreatment Adherence and Compliance
dc.titleA Mediterranean Diet Is Positively Associated with Bone and Muscle Health in a Non-Mediterranean Region in 25,450 Men and Women from EPIC-Norfolk.
dc.typeArticle
prism.issueIdentifier4
prism.publicationDate2020
prism.publicationNameNutrients
prism.volume12
dc.identifier.doi10.17863/CAM.78631
dc.identifier.doi10.17863/CAM.78631
dcterms.dateAccepted2020-04-17
rioxxterms.versionofrecord10.3390/nu12041154
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-04-21
dc.contributor.orcidMulligan, Angela [0000-0001-5546-971X]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidWelch, Ailsa A [0000-0002-6702-3704]
dc.identifier.eissn2072-6643
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idMedical Research Council (G0500300)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
cam.issuedOnline2020-04-21


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International