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dc.contributor.authorHare, Lucy
dc.contributor.authorBurke, GA Amos
dc.contributor.authorTurner, Suzanne
dc.date.accessioned2021-12-02T02:28:22Z
dc.date.available2021-12-02T02:28:22Z
dc.date.issued2021-11-29
dc.identifier.issn2072-6694
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331205
dc.description.abstractNon-Hodgkin lymphoma (NHL) is the third most common malignancy diagnosed in children. The vast majority of paediatric NHL are either Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), anaplastic large cell lymphoma (ALCL), or lymphoblastic lymphoma (LL). Multi-agent chemotherapy is used to treat all of these types of NHL, and survival is over 90% but the chemotherapy regimens are intensive, and outcomes are generally poor if relapse occurs. Therefore, targeted therapies are of interest as potential solutions to these problems. However, the major problem with all targeted agents is the development of resistance. Mechanisms of resistance are not well understood, but increased knowledge will facilitate optimal management strategies through improving our understanding of when to select each targeted agent, and when a combinatorial approach may be helpful. This review summarises currently available knowledge regarding resistance to targeted therapies used in paediatric anaplastic lymphoma kinase (ALK)-positive ALCL. Specifically, we outline where gaps in knowledge exist, and further investigation is required in order to find a solution to the clinical problem of drug resistance in ALCL.
dc.publisherMDPI AG
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleResistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.
dc.typeArticle
prism.publicationNameCancers (Basel)
dc.identifier.doi10.17863/CAM.78652
dcterms.dateAccepted2021-11-25
rioxxterms.versionofrecord10.3390/cancers13236003
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-25
dc.contributor.orcidBurke, GA Amos [0000-0003-2671-9972]
dc.contributor.orcidTurner, Suzanne [0000-0002-8439-4507]
dc.identifier.eissn2072-6694
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-11-29
cam.orpheus.successTue Feb 01 19:02:22 GMT 2022 - Embargo updated*
rioxxterms.freetoread.startdate2021-11-29


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